Evidence map›Paper›PMID 38227951›Full record

ArticleThe Journal of organic chemistry2024

Synthesis of Boron-Containing Nucleoside Analogs.

Latifah M Alhthlol, Christopher L Orme, Ben S Jefferis, Sarah A Herter, Halee E Kemper, John W Tomsho

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Latifah M AlhthlolDepartment of Chemistry & Biochemistry, St Joseph's University, University City Campus, 600 South 43rd Street, Philadelphia, Pennsylvania 19104, United States.
Christopher L OrmeDepartment of Chemistry & Biochemistry, St Joseph's University, University City Campus, 600 South 43rd Street, Philadelphia, Pennsylvania 19104, United States.
Ben S JefferisDepartment of Chemistry & Biochemistry, St Joseph's University, University City Campus, 600 South 43rd Street, Philadelphia, Pennsylvania 19104, United States.
Sarah A HerterDepartment of Chemistry & Biochemistry, St Joseph's University, University City Campus, 600 South 43rd Street, Philadelphia, Pennsylvania 19104, United States.
Halee E KemperDepartment of Chemistry & Biochemistry, St Joseph's University, University City Campus, 600 South 43rd Street, Philadelphia, Pennsylvania 19104, United States.
John W TomshoDepartment of Chemistry & Biochemistry, St Joseph's University, University City Campus, 600 South 43rd Street, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0001-9972-8728

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the last century, nucleoside-based therapeutics have demonstrated remarkable effectiveness in the treatment of a wide variety of diseases from cancer to HIV. In addition, boron-containing drugs have recently emerged as an exciting and fruitful avenue for medicinal therapies. However, borononucleosides have largely been unexplored in the context of medicinal applications. Herein, we report the synthesis, isolation, and characterization of two novel boron-containing nucleoside compound libraries which may find utility as therapeutic agents. Our synthetic strategy employs efficient one-step substitution reactions between a diverse variety of nucleoside scaffolds and an assortment of

Indexed as

BoronNucleosidesAlkylationBoron CompoundsBoronBoron CompoundsNucleosides

Identifiers

PMID38227951
PMCPMC10845115

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.