Evidence map›Paper›PMID 38227784›Full record

ArticleChembiochem : a European journal of chemical biology2024

Preclinical Evaluation of Azabenzimidazole-Based PET Radioligands for γ-8 Dependent Transmembrane AMPA Receptor Regulatory Protein Imaging.

Jiahui Chen, Yinlong Li, Qingzhen Yu, Jimmy S Patel, Xin Zhou, Kuo Zhang, Jian Rong, Chunyu Zhao, Ahmad F Chaudhary, Wei Zhang and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Jiahui ChenDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA-02114, USA.ORCID 0000-0001-9186-1110
Yinlong LiDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA-02114, USA.
Qingzhen YuDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA-02114, USA.
Jimmy S PatelDepartment of Radiology and Imaging Science, Emory University School of Medicine, Atlanta, GA-30322, USA.
Xin ZhouDepartment of Radiology and Imaging Science, Emory University School of Medicine, Atlanta, GA-30322, USA.
Kuo ZhangDepartment of Radiology and Imaging Science, Emory University School of Medicine, Atlanta, GA-30322, USA.
Jian RongDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA-02114, USA.
Chunyu ZhaoDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA-02114, USA.
Ahmad F ChaudharyDepartment of Radiology and Imaging Science, Emory University School of Medicine, Atlanta, GA-30322, USA.
Wei ZhangDepartment of Radiology and Imaging Science, Emory University School of Medicine, Atlanta, GA-30322, USA.
Chunyang BiDepartment of Radiology and Imaging Science, Emory University School of Medicine, Atlanta, GA-30322, USA.
Zhendong SongDepartment of Radiology and Imaging Science, Emory University School of Medicine, Atlanta, GA-30322, USA.
April T DavenportDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC-27157, USA.
James B DaunaisDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC-27157, USA.
Achi HaiderDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA-02114, USA.
Lee CollierDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA-02114, USA.
Hongjie YuanDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA-30322, USA.
Steven LiangDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA-02114, USA.ORCID 0000-0003-1413-6315
Emory University · USHarvard University · USWake Forest University · US

Funding

Early Stress & Alcoholism: Neurobiological AnalysisU01AA014106 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FRIEDMAN, DAVID P · 2003 to 2011
$3.4M
Subtype-selective NMDA ligands for Alzheimer's DiseaseR01AG075444 · NIA · EMORY UNIVERSITY · PI LIANG, STEVEN H · 2022 to 2025
$3.1M
AMPAR ligand discovery for Alzheimer's diseaseRF1AG073428 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI LIANG, STEVEN H · 2021 to 2021
$2.3M
Translation of GluN2B-selective PET radiopharmaceuticals in Alzheimers patientsR01AG083084 · NIA · EMORY UNIVERSITY · PI LAH, JAMES J, LIANG, STEVEN H · 2023 to 2025
$2.3M
AMPAR ligand discovery for Alzheimer's diseaseR01AG073428 · NIA · EMORY UNIVERSITY · PI LIANG, STEVEN H · 2024 to 2025
$1.5M
Advancing Neuroimaging in Nonhuman PrimatesR21AA028007 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAUNAIS, JAMES B · 2020 to 2021
$396k
NIAAA NIH HHS R21 AA028007NIAAA NIH HHS U01 AA014106NIA NIH HHS R01 AG073428NIA NIH HHS R01 AG075444NIA NIH HHS R01 AG083084NIA NIH HHS RF1 AG073428NIH HHS AA028007NIH HHS AG073428NIH HHS AG075444NIH HHS MH120197NIH HHS U01AA014106
6 · The paper itself

Abstract

AMPA glutamate receptors (AMPARs) play a pivotal role in excitatory neurotransmission, particularly in the hippocampus where the TARP γ-8 subunit is enriched and serves as a target for emerging anti-epileptic drugs. To enable in vivo visualization of TARP γ-8 distribution and expression by positron emission tomography (PET), this study focuses on the development of novel

Indexed as

Positron-Emission TomographyReceptors, AMPAAnimalsHippocampusRatsReceptors, AMPAAMPA glutamate receptorscentral nervous system (CNS)fluorine 18 (18F)positron emission tomography (PET)TARP γ-8

Identifiers

PMID38227784
PMCPMC12227307
OpenAlexW4390903317

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.