ArticleVeterinary medicine and science2024
Serum pregnancy-associated glycoprotein profiles during early gestation in Karya and Konya Merino sheep.
Article in Veterinary medicine and science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 3 citations in OpenAlex.
- A Narrative Review of Early Pregnancy Diagnosis Technologies for Livestock: From Conventional to Intelligent Systems.Animals : an open access journal from MDPI · 2026Review
- Maternal Undernutrition Effect on Pregnancy-Associated Glycoprotein (PAG) Concentration in Sheep Carrying Single and Multiple Fetuses.Animals : an open access journal from MDPI · 2024Article
- The Utilization of a Pregnancy-Associated Glycoprotein Profile and PAG/P4 Ratio Biomarker for the Diagnosis of Pseudopregnancy in Dairy Goats.Veterinary sciences · 2024Article
- Serum pregnancy-associated glycoprotein profiles during early gestation in Karya and Konya Merino sheep.Veterinary medicine and science · 2024Article
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReported as being expressed by mono- and binucleate placental cells, pregnancy-associated glycoproteins (PAGs) are released into the blood circulation from the ruminant placenta. Circulating gestational PAGs levels may differ between sheep breeds.
objectiveThis study was aimed at the close monitoring of the serum PAGs profiles of Karya and Konya Merino sheep during early pregnancy.
methodsFifteen Karya and 15 Konya Merino ewes were synchronized by a 12-day treatment with progesterone-impregnated intravaginal sponges. After the sponges were withdrawn, the ewes were administered 400 IU of equine chorionic gonadotropin. The ewes were allowed to mate naturally, and all animals were sampled for blood as of the day of mating (day 0) at weeks 1, 2, 3, 4 and 5. Pregnancy diagnoses were made by transabdominal ultrasonography at week 5. At weeks 6, 7, 8, 9 and 11, blood samples were collected only from the pregnant ewes. The blood samples were centrifuged at 3000 × g, and extracted sera were stored at -20°C until being used for laboratory analyses. Serum PAGs levels were determined with the aid of a commercial PAG-enzyme-linked immunosorbent assay test originally developed for pregnancy diagnosis in cattle. Differences in the between the PAGs levels throughout pregnancy and the group effect (Karya and Konya Merino) were determined with a two-way mixed analysis of variance. Pairwise comparisons were made using a Bonferroni adjustment.
resultsPAGs levels showed a linear increase with the advance of pregnancy in both Karya and Konya Merino sheep. No difference was detected between the breeds for serum PAGs levels. The serum PAGs levels of the pregnant and non-pregnant ewes differed as of the fourth week.
conclusionThe serum PAGs levels of the Karya and Konya Merino ewes were similar during the first 11 weeks of gestation, and pregnancy diagnosis could be made based on serum PAGs levels as of the 4th week in both breeds.
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