Evidence map›Paper›PMID 38227382›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Salivary Amylase-Responsive Buccal Tablets Wipe Out Chemotherapy-Rooted Refractory Oral Mucositis.

Yan Zhang, Taixia Wang, Xiulin Dong, Chunyan Zhu, Qiuxia Peng, Chang Liu, Yifeng Zhang, Fubo Chen, Kun Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
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  3. [Oral mucosal administration].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yan ZhangDepartment of Medical Ultrasound and Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Tongji University, NO. 301 Yan-chang-zhong Road, Shanghai, 200072, China.
Taixia WangDepartment of Medical Ultrasound and Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Tongji University, NO. 301 Yan-chang-zhong Road, Shanghai, 200072, China.
Xiulin DongDepartment of Pharmacy and Central Laboratory, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, No. 32, West Second Section, First Ring Road, Chengdu, 610072, China.
Chunyan ZhuDepartment of Medical Ultrasound and Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Tongji University, NO. 301 Yan-chang-zhong Road, Shanghai, 200072, China.
Qiuxia PengDepartment of Medical Ultrasound and Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Tongji University, NO. 301 Yan-chang-zhong Road, Shanghai, 200072, China.
Chang LiuDepartment of Medical Ultrasound and Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Tongji University, NO. 301 Yan-chang-zhong Road, Shanghai, 200072, China.
Yifeng ZhangDepartment of Medical Ultrasound and Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Tongji University, NO. 301 Yan-chang-zhong Road, Shanghai, 200072, China.
Fubo ChenDepartment of Medical Ultrasound and Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Tongji University, NO. 301 Yan-chang-zhong Road, Shanghai, 200072, China.
Kun ZhangDepartment of Pharmacy and Central Laboratory, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, No. 32, West Second Section, First Ring Road, Chengdu, 610072, China.ORCID 0000-0002-6971-1164
Tongji University · CNSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · CN

Funding

Excellent Young Scientists Fund for National Natural Science Foundation of China 82022033Fundamental Research Funds for the Central Universities 22120210561Shanghai Pujiang Program 22PJD056
6 · The paper itself

Abstract

Oral mucositis (OM) is the most common and refractory complication of cancer chemotherapy and radiotherapy, severely affecting patients' life quality, lowering treatment tolerance, and discouraging patient compliance. Current OM delivery systems mostly affect the comfort of patient use and lead to poor compliance and unsatisfactory effects. Herein, salivary amylases (SAs)-responsive buccal tablets consisting of porous manganese-substituted Prussian blue (PMPB) nanocubes (NCs), anti-inflammatory apremilast (Apr) and starch controller have been engineered. PMPB NCs with large surface area can serve as carriers to load Apr, and their multienzyme-mimicking activity enables them to scavenge reactive oxygen species (ROS), which thus synergize with Apr to mitigate inflammation. More significantly, the starch controller can respond to abundant SAs in the oral cavity and realize the cascade, continuous, and complete drug release after enzymatic decomposition, which not only aids with high tissue affinity to prolong the resistance time but also improves the comfort of use. The preclinical study reveals that contributed by the above actions, such buccal tablets mitigate inflammation, promote endothelium proliferation and migration, and accelerate wound healing for repressing chemotherapy-originated intractable OM with positive oral microenvironment and shorter recovery time, thus holding high potentials in clinical translation.

Indexed as

StomatitisAmylasesHumansInflammationStarchTabletsAmylasesStarchTabletsanti-inflammatorybuccal tabletsrefractory oral mucositissalivary amylase responsewound healing

Identifiers

PMID38227382
PMCPMC10962474
OpenAlexW4390906666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.