Evidence map›Paper›PMID 38227180›Full record

ArticleCanadian journal of public health = Revue canadienne de sante publique2024

Excess risk of COVID-19 infection and mental distress in healthcare workers during successive pandemic waves: Analysis of matched cohorts of healthcare workers and community referents in Alberta, Canada.

Jean-Michel Galarneau, France Labrèche, Quentin Durand-Moreau, Shannon Ruzycki, Anil Adisesh, Igor Burstyn, Tanis Zadunayski, Nicola Cherry

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of public health = Revue canadienne de sante publique, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Anti-SARS-CoV-2 Antibody Levels in a Cohort of Health Care Workers Before and After the Omicron Wave in Canada.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Jean-Michel GalarneauDivision of Preventive Medicine, University of Alberta, Edmonton, AB, Canada.
France LabrècheResearch Department, Institut de recherche Robert-Sauvé en santé et en sécurité du travail, Montréal, QC, Canada.
Quentin Durand-MoreauDivision of Preventive Medicine, University of Alberta, Edmonton, AB, Canada.
Shannon RuzyckiDepartment of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Anil AdiseshDivision of Occupational Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Igor BurstynDepartment of Environmental and Occupational Health, Drexel University, Philadelphia, PA, USA.
Tanis ZadunayskiDivision of Preventive Medicine, University of Alberta, Edmonton, AB, Canada.
Nicola CherryDivision of Preventive Medicine, University of Alberta, Edmonton, AB, Canada. ncherry@ualberta.ca.ORCID 0000-0002-3147-1548
University of Alberta · CADrexel University · USInstitut de recherche Robert-Sauvé en santé et en sécurité du travail · CAUniversity of Calgary · CAUniversity of Toronto · CA

Funding

CIHR FRN 173209
6 · The paper itself

Abstract

objectivesTo investigate changes in risk of infection and mental distress in healthcare workers (HCWs) relative to the community as the COVID-19 pandemic progressed.

methodsHCWs in Alberta, Canada, recruited to an interprovincial cohort, were asked consent to link to Alberta's administrative health database (AHDB) and to information on COVID-19 immunization and polymerase chain reaction (PCR) testing. Those consenting were matched to records of up to five community referents (CRs). Physician diagnoses of COVID-19 were identified in the AHDB from the start of the pandemic to 31 March 2022. Physician consultations for mental health (MH) conditions (anxiety, stress/adjustment reaction, depressive) were identified from 1 April 2017 to 31 March 2022. Risks for HCW relative to CR were estimated by fitting wave-specific hazard ratios.

resultsEighty percent (3050/3812) of HCWs consented to be linked to the AHDB; 97% (2959/3050) were matched to 14,546 CRs. HCWs were at greater risk of COVID-19 overall, with first infection defined from either PCR tests (OR=1.96, 95%CI 1.76-2.17) or physician records (OR=1.33, 95%CI 1.21-1.45). They were also at increased risk for each of the three MH diagnoses. In analyses adjusted for confounding, risk of COVID-19 infection was higher than for CRs early in the pandemic and during the fifth (Omicron) wave. The excess risk of stress/adjustment reactions (OR=1.52, 95%CI 1.35-1.71) and depressive conditions (OR=1.39, 95%CI 1.24-1.55) increased with successive waves during the epidemic, peaking in the fourth wave.

conclusionHCWs were at increased risk of both COVID-19 and mental ill-health with the excess risk continuing late in the pandemic.

Indexed as

COVID-19Mental DisordersAlbertaHealth PersonnelHumansPandemicsCase-referentCOVID-19Healthcare workersMental healthPandemic wave

Identifiers

PMID38227180
PMCPMC11006634
OpenAlexW4390919529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.