ArticleHypertension (Dallas, Tex. : 1979)2024
Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure.
Open access · greenAbstract read
In one paragraph
Article in Hypertension (Dallas, Tex. : 1979), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 7 citations in OpenAlex.
- Gene-environment interaction modifies the association between hyperinsulinemia and serum urate levels through SLC22A12.The Journal of clinical investigation · 2025Trial
- Nutrient-Sensitive Epigenetic Modifiers as Candidate Biomarkers of Metabolic Dysfunction in Obesity: A Nutrigenomic Review.International journal of molecular sciences · 2026Review
- Genetic factors contributing to atherosclerosis.Current opinion in cardiology · 2026Review
- Nuclear regulatory disturbances precede and predict the development of Type-2 diabetes in Asian populations.medRxiv : the preprint server for health sciences · 2025Article
- Harnessing the power of genomics in hypertension: tip of the iceberg?Cambridge prisms. Precision medicine · 2025Review
- Genome-Wide Approach of Gene-Nutrient Intake Interaction Study for Essential Hypertension in a Large Korean Cohort (KoGES).Nutrients · 2024Article
- Polygenic Interactions With Environmental Exposures in Blood Pressure Regulation: The HUNT Study.Journal of the American Heart Association · 2024Article
- Diet to Stop Hypertension: Should Fats be Included?Current hypertension reports · 2024Review
Corrections and comments
- Update of
Authors and funding
47 authors at 20 institutions in 9 countries.
Mélanie GuiretteFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA (M.G., J.L., J.M.).ORCID 0000-0002-8878-2224
Jessie LanFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA (M.G., J.L., J.M.).
Nicola M McKeownPrograms of Nutrition, Department of Health Sciences, Sargent College of Health & Rehabilitation Sciences, Boston University, MA (N.M.M.).
Michael R BrownHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (M.R.B., H.C., P.S.d.V., A.C.M.).ORCID 0000-0002-5235-9037
Han ChenHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (M.R.B., H.C., P.S.d.V., A.C.M.).ORCID 0000-0002-9510-4923
Paul S de VriesHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (M.R.B., H.C., P.S.d.V., A.C.M.).ORCID 0000-0003-0964-0111
Hyunju KimDepartment of Epidemiology (H.K., A.M.F.), Cardiovascular Health Research Unit, University of Washington, Seattle, WA.ORCID 0000-0002-1707-7018
Casey M RebholzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (C.M.R.).ORCID 0000-0002-5442-8745
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston (M.R.B., H.C., P.S.d.V., A.C.M.).ORCID 0000-0001-6381-4296
Traci M BartzDepartments of Biostatistics and Medicine (T.M.B.), Cardiovascular Health Research Unit, University of Washington, Seattle, WA.ORCID 0000-0003-3403-8763
Amanda M FrettsDepartment of Epidemiology (H.K., A.M.F.), Cardiovascular Health Research Unit, University of Washington, Seattle, WA.ORCID 0000-0002-5358-2345
Xiuqing GuoThe Lundquist Institute at Harbor-University of California, Los Angeles, Torrance, CA (X.G.).ORCID 0000-0002-5264-5068
Rozenn N LemaitreDepartment of Medicine (R.N.L.), Cardiovascular Health Research Unit, University of Washington, Seattle, WA.ORCID 0000-0002-7038-1844
Ching-Ti LiuBiostatistics, Boston University School of Public Health, MA (C.-T.L.).ORCID 0000-0002-0703-0742
Raymond NoordamDepartment of Internal Medicine, Section of Gerontology and Geriatrics (R.N.), Leiden University Medical Center, the Netherlands.ORCID 0000-0001-7801-809X
Renée de MutsertDepartment of Clinical Epidemiology (R.d.M., F.R.R.), Leiden University Medical Center, the Netherlands.
Frits R RosendaalDepartment of Clinical Epidemiology (R.d.M., F.R.R.), Leiden University Medical Center, the Netherlands.ORCID 0000-0003-2558-7496
Carol A WangSchool of Medicine and Public Health, University of Newcastle, NSW, Australia (C.A.W., C.E.P).ORCID 0000-0002-4301-3974
Lawrence J BeilinMedical School, Royal Perth Hospital Unit, University of Western Australia, Crawley (L.J.B., T.A.M.).ORCID 0000-0003-4853-7360
Trevor A MoriMedical School, Royal Perth Hospital Unit, University of Western Australia, Crawley (L.J.B., T.A.M.).ORCID 0000-0002-5264-9229
Wendy H OddyMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia (W.H.O.).
Craig E PennellSchool of Medicine and Public Health, University of Newcastle, NSW, Australia (C.A.W., C.E.P).ORCID 0000-0002-0937-6165
Jin Fang ChaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System (J.F.C., C.W., R.M.v.D., E.S.T., X.S.).ORCID 0000-0003-3770-1137
Clare WhittonSaw Swee Hock School of Public Health, National University of Singapore and National University Health System (J.F.C., C.W., R.M.v.D., E.S.T., X.S.).ORCID 0000-0003-1991-2432
Rob M van DamSaw Swee Hock School of Public Health, National University of Singapore and National University Health System (J.F.C., C.W., R.M.v.D., E.S.T., X.S.).ORCID 0000-0002-7354-8734
Jianjun LiuGenome Institute of Singapore, Agency for Science, Technology and Research (J.L.).ORCID 0000-0002-3255-3019
E Shyong TaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System (J.F.C., C.W., R.M.v.D., E.S.T., X.S.).ORCID 0000-0003-2929-8966
Xueling SimSaw Swee Hock School of Public Health, National University of Singapore and National University Health System (J.F.C., C.W., R.M.v.D., E.S.T., X.S.).ORCID 0000-0002-1233-7642
Marian L NeuhouserDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA (M.L.N., C.K., L.F.T.).
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA (M.L.N., C.K., L.F.T.).
Lesley F TinkerDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA (M.L.N., C.K., L.F.T.).
Nora FranceschiniDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill (N.F.).ORCID 0009-0001-8346-3662
TianXiao HuanFramingham Heart Study and Population Sciences Branch, National Heart, Lung, and Blood Institute, MA (T.H., D.L.).
Thomas W WinklerDepartment of Genetic Epidemiology, University of Regensburg, Germany (T.W.W.).ORCID 0000-0003-0292-5421
Amy R BentleyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD (A.R.B.).ORCID 0000-0002-0827-9101
W James GaudermanDivision of Biostatistics, Department of Population and Public Health Sciences, University of Southern California (W.J.G.).ORCID 0000-0002-6626-9091
Luc HeerkensDivision of Human Nutrition and Health, Wageningen University & Research, the Netherlands (L.H.).ORCID 0000-0003-0460-7056
Toshiko TanakaLongitudinal Studies Section, National Institute on Aging, Baltimore, MD (T.T.).
Jeroen van RooijDepartment of Internal Medicine (J.v.R.), Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Patricia B MunroeCentre of Clinical Pharmacology & Precision Medicine, William Harvey Research Institute, Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London, United Kingdom (P.B.M., H.R.W.).ORCID 0000-0002-4176-2947
Helen R WarrenCentre of Clinical Pharmacology & Precision Medicine, William Harvey Research Institute, Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London, United Kingdom (P.B.M., H.R.W.).ORCID 0000-0003-0511-1386
Trudy VoortmanDepartment of Epidemiology (T.V.), Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID 0000-0003-2830-6813
Honglei ChenDepartment of Epidemiology and Biostatistics College of Human Medicine, Michigan State University, East Lansing (H.C.).ORCID 0000-0003-3446-7779
D C RaoCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R.).ORCID 0009-0006-8538-2141
Daniel LevyFramingham Heart Study and Population Sciences Branch, National Heart, Lung, and Blood Institute, MA (T.H., D.L.).ORCID 0000-0003-1843-8724
Jiantao MaFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA (M.G., J.L., J.M.).ORCID 0000-0001-7478-7203
CHARGE Gene-Lifestyle Interactions Working Group
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZALeiden University Medical Center · NLNational University Health System · SGThe University of Texas Health Science Center at Houston · USTufts University · USUniversity of Washington · USErasmus MC · NLFramingham Heart Study · USHunter Medical Research Institute · AUQueen Mary University of London · GBRoyal Perth Hospital · AUAgency for Science, Technology and Research · SGBoston University · USCenter for Human Genetics · USInstitute for Medical Informatics and Biostatistics · CHJohns Hopkins University · USLos Angeles Biomedical Research Institute · USMassachusetts College of Pharmacy and Health Sciences · USMichigan State University · USMilken Institute · US
Funding
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1MStatistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Paul Marjoram · 2016 to 2026
$25.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MA Multi-Ancestry Study of Gene-Lifestyle Interactions and Multi-Omics in Cardiometabolic TraitsR01HL156991 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2021 to 2024
$8.8MA Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular TraitsR01HL118305 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2014 to 2017
$8.3MDietary factors, biomarkers, metabolic pathways related to non-alcoholic fatty liver diseaseK22HL135075 · NHLBI · TUFTS UNIVERSITY BOSTON · PI MA, JIANTAO · 2019 to 2021
$747kProteomic and epigenetic alterations associated with plant-based diets and CVDK01HL168232 · NHLBI · UNIVERSITY OF WASHINGTON · PI Hyunju Kim · 2023 to 2026
$683kNCI NIH HHS P01 CA196569NHLBI NIH HHS K01 HL168232NHLBI NIH HHS K22 HL135075NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL118305NHLBI NIH HHS R01 HL156991
Abstract
backgroundThe Dietary Approaches to Stop Hypertension (DASH) diet score lowers blood pressure (BP). We examined interactions between genotype and the DASH diet score in relation to systolic BP.
methodsWe analyzed up to 9 420 585 single nucleotide polymorphisms in up to 127 282 individuals of 6 population groups (91% of European population) from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (n=35 660) and UK Biobank (n=91 622) and performed European population-specific and cross-population meta-analyses.
resultsWe identified 3 loci in European-specific analyses and an additional 4 loci in cross-population analyses at
conclusionsWe demonstrated gene-DASH diet score interaction effects on systolic BP in several loci. Studies with larger diverse populations are needed to validate our findings.
Indexed as
Dietary Approaches To Stop HypertensionHypertensionBlood PressureDietGenotypeHumansblood pressurecardiovascular diseasesgene-environment interactionhypertensionUK Biobank
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.