Evidence map›Paper›PMID 38226424›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

A Catalytic Three-Component Aminofluorination of Unactivated Alkenes with Electron-Rich Amino Sources.

Junchao Dong, Yujie Liang, Yang Li, Wei Guan, Qian Zhang, Junkai Fu

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Junchao DongJilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis and Institute of Functional Material Chemistry, Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
Yujie LiangInstitute of Functional Material Chemistry, Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
Yang LiJilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis and Institute of Functional Material Chemistry, Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
Wei GuanInstitute of Functional Material Chemistry, Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
Qian ZhangJilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis and Institute of Functional Material Chemistry, Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
Junkai FuJilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis and Institute of Functional Material Chemistry, Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.ORCID https://orcid.org/0000-0002-7714-8818

Funding

Jilin Provincial Scientific and Technological Development Program 20230508107RCNational Natural Science Foundation of China 21773025National Natural Science Foundation of China 21971034National Natural Science Foundation of China 22371036Postdoctoral Research Foundation of China 2022M723023Shenzhen Science and Technology Innovation Program RCB20221008093230037
6 · The paper itself

Abstract

We present herein a copper-catalyzed three-component aminofluorination of unactivated alkenes with N-bromodialkylamines and readily available nucleophilic fluoride under the assistance of a bidentate auxiliary. This protocol exhibits excellent functional group tolerance toward a wide range of unactivated alkenes and N-bromodialkylamines to furnish the corresponding β-fluoroalkylamines in a highly regio- and diastereoselective manner. The appropriate choice of nucleophilic fluoro source is essential to make this reaction a reality. Further DFT calculations show that the exothermic ion exchange between external fluoride ion and Cu(II) intermediate provides additional driving force to the irreversible migratory insertion, which offsets the unfavorable reaction energetics associated with the subsequent C(sp

Indexed as

aminofluorinationC–F reductive eliminationcopper(III)unactivated alkenesβ‐fluoroamine

Identifiers

PMID38226424
PMCPMC10966579

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.