Evidence map›Paper›PMID 38226320›Full record

ArticleJID innovations : skin science from molecules to population health2024

Therapeutic TNF Inhibitors Exhibit Differential Levels of Efficacy in Accelerating Cutaneous Wound Healing.

Yonghao Cao, Bohdan P Harvey, Liang Jin, Susan Westmoreland, Jing Wang, Munish Puri, Yingli Yang, Holly M Robb, Sultan Tanriverdi, Chenqi Hu and 9 more

Open access · goldAbstract read
In one paragraph

Article in JID innovations : skin science from molecules to population health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Yonghao CaoTransformational and Translational Immunology Discovery, AbbVie Bioresearch Center, Worcester, Massachusetts, USA.
Bohdan P HarveyTransformational and Translational Immunology Discovery, AbbVie Bioresearch Center, Worcester, Massachusetts, USA.
Liang JinDMPK-BA, AbbVie Bioresearch Center, Worcester, Massachusetts, USA.
Susan WestmorelandPhamacology and Pathology, AbbVie Bioresearch Center, Worcester, Massachusetts, USA.
Jing WangImmunology Computational Biology, AbbVie Cambridge Research Center, Cambridge, Massachusetts, USA.
Munish PuriPhamacology and Pathology, AbbVie Bioresearch Center, Worcester, Massachusetts, USA.
Yingli YangPhamacology and Pathology, AbbVie Bioresearch Center, Worcester, Massachusetts, USA.
Holly M RobbDiscovery Research, AbbVie, North Chicago, Illinois, USA.
Sultan TanriverdiTransformational and Translational Immunology Discovery, AbbVie Bioresearch Center, Worcester, Massachusetts, USA.
Chenqi HuDMPK-BA, AbbVie Bioresearch Center, Worcester, Massachusetts, USA.
Xue WangDMPK-BA, AbbVie Bioresearch Center, Worcester, Massachusetts, USA.
Xiaofeng XinGlobal Biologics, AbbVie Bioresearch Center, Worcester, Massachusetts, USA.
Yingchun LiuImmunology Computational Biology, AbbVie Cambridge Research Center, Cambridge, Massachusetts, USA.
Michael P MacorittoImmunology Computational Biology, AbbVie Cambridge Research Center, Cambridge, Massachusetts, USA.
Kathleen M SmithImmunology Computational Biology, AbbVie Cambridge Research Center, Cambridge, Massachusetts, USA.
Yu TianDMPK-BA, AbbVie Bioresearch Center, Worcester, Massachusetts, USA.
Kevin WhiteTransformational and Translational Immunology Discovery, AbbVie Bioresearch Center, Worcester, Massachusetts, USA.
Timothy R D J RadstakeTransformational and Translational Immunology Discovery, AbbVie Bioresearch Center, Worcester, Massachusetts, USA.
Zehra KaymakcalanTransformational and Translational Immunology Discovery, AbbVie Bioresearch Center, Worcester, Massachusetts, USA.
AbbVie (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adalimumab but neither etanercept nor certolizumab-pegol has been reported to induce a wound-healing profile in vitro by regulating macrophage differentiation and matrix metalloproteinase expression, which may underlie the differences in efficacy between various TNF-α inhibitors in impaired wound healing in patients with hidradenitis suppurativa, a chronic inflammatory skin disease. To examine and compare the efficacy of various TNF inhibitors in cutaneous wound healing in vivo, a human TNF knock-in Lepr

Indexed as

Hidradenitis suppurativaTNF inhibitorsWound healing

Identifiers

PMID38226320
PMCPMC10788510
OpenAlexW4388996524

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.