Evidence map›Paper›PMID 38226265›Full record

ArticleHeliyon2024

The neuroprotection of controlled decompression after traumatic epidural intracranial hypertension through suppression of autophagy via PI3K/Akt signaling pathway.

Yuanyuan Che, Wei Wu, Xiao Qian, Zhengwei Sheng, Wang Zhang, Jie Zheng, Junhui Chen, Yuhai Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yuanyuan CheWuxi Clinical College of Anhui Medical University, The Fifth Clinical Medical College of Anhui Medical University, Wuxi, Jiangsu, 214044, China.
Wei WuDepartment of Laboratory, The 904th Hospital of PLA, Wuxi, Jiangsu, China.
Xiao QianWuxi Clinical College of Anhui Medical University, The Fifth Clinical Medical College of Anhui Medical University, Wuxi, Jiangsu, 214044, China.
Zhengwei ShengWuxi Clinical College of Anhui Medical University, The Fifth Clinical Medical College of Anhui Medical University, Wuxi, Jiangsu, 214044, China.
Wang ZhangWuxi Clinical College of Anhui Medical University, The Fifth Clinical Medical College of Anhui Medical University, Wuxi, Jiangsu, 214044, China.
Jie ZhengWuxi Clinical College of Anhui Medical University, The Fifth Clinical Medical College of Anhui Medical University, Wuxi, Jiangsu, 214044, China.
Junhui ChenWuxi Clinical College of Anhui Medical University, The Fifth Clinical Medical College of Anhui Medical University, Wuxi, Jiangsu, 214044, China.
Yuhai WangWuxi Clinical College of Anhui Medical University, The Fifth Clinical Medical College of Anhui Medical University, Wuxi, Jiangsu, 214044, China.
Anhui Medical University · CN81th Hospital of PLA · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute intracranial hypertension (AIH) is a common and tricky symptom that inflicts upon patients after traumatic brain injury (TBI). A variety of clinical options have been applied for the management of AIH, such as physiotherapy, medication, surgery and combination therapy. Specifically, controlled decompression (CDC) alleviates the extent of brain injury and reduces the incidence of a series of post-TBI complications, thereby enhancing the prognosis of patients suffering from acute intracranial hypertension. The objective of the present project is to illuminate the potential molecular mechanism that underlies the neuroprotective effects of CDC in a rat model of traumatic epidural intracranial hypertension (TEIH). Herein, we observed the functional recovery, the degree of brain edema, the level of apoptosis, the expressions of neuronal cell autophagy-related signaling pathway proteins (including Akt,

Indexed as

AutophagyControlled decompressionEarly brain injuryPI3K/Akt signaling pathwayTraumatic epidural intracranial hypertension

Identifiers

PMID38226265
PMCPMC10788442
OpenAlexW4389955817

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.