Evidence map›Paper›PMID 38226162›Full record

ArticleiScience2024

Presenilin-1 in smooth muscle cells facilitates hypermuscularization in elastin aortopathy.

Junichi Saito, Jui M Dave, Freddy Duarte Lau, Daniel M Greif

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Elastin Regulates Vascular Smooth Muscle Cell Behavior During Development and in Diseases.Pediatrics international : official journal of the Japan Pediatric Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Junichi SaitoYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University, New Haven, CT 06511, USA.
Jui M DaveYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University, New Haven, CT 06511, USA.
Freddy Duarte LauYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University, New Haven, CT 06511, USA.
Daniel M GreifYale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University, New Haven, CT 06511, USA.
Yale University · USYale Cancer Center · US

Funding

Novel vascular smooth muscle cell progenitors in development and diseaseR35HL150766 · NHLBI · YALE UNIVERSITY · PI Daniel Greif · 2020 to 2026
$7.0M
Epigenetic-mediated Notch pathway activation promotes elastin aortopathyR01HD110059 · NICHD · YALE UNIVERSITY · PI Daniel Greif, Kathleen Ann Martin · 2023 to 2026
$2.6M
Coordinated regulation of vascular smooth muscle phenotype by p300, CBP, and TET2R01HL146101 · NHLBI · YALE UNIVERSITY · PI GALLAGHER, PATRICK G, MARTIN, KATHLEEN ANN · 2019 to 2022
$2.2M
Aging and clonality in atherosclerosisR21AG062202 · NIA · YALE UNIVERSITY · PI FERNANDEZ HERNANDO, CARLOS, GREIF, DANIEL · 2019 to 2020
$461k
Pericyte angiopoietin2 and neonatal intracranial hemorrhageR21NS123469 · NINDS · YALE UNIVERSITY · PI GREIF, DANIEL · 2021 to 2021
$461k
NHLBI NIH HHS R01 HL146101NHLBI NIH HHS R35 HL150766NIA NIH HHS R21 AG062202NICHD NIH HHS R01 HD110059NINDS NIH HHS R21 NS123469
6 · The paper itself

Abstract

Smooth muscle cell (SMC) accumulation is central to the pathogenesis of elastin-defective arterial diseases, including supravalvular aortic stenosis (SVAS). We previously demonstrated that elastin insufficiency activates Notch signaling in aortic SMCs. Activation of Notch is catalyzed by the enzyme gamma-secretase, but the role of catalytic subunits presenilin (PSEN)-1 or PSEN-2 in elastin aortopathy is not defined. Genetic approaches reveal that endothelial cell-specific

Indexed as

Biological sciencesNatural sciencesPhysiology

Identifiers

PMID38226162
PMCPMC10788461
OpenAlexW4389670585

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.