Evidence map›Paper›PMID 38226160›Full record

ArticleiScience2024

SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells.

Oleksandra Kalnytska, Per Qvist, Séverine Kunz, Thomas Conrad, Thomas E Willnow, Vanessa Schmidt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Oleksandra KalnytskaMolecular Cardiovascular Research, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.
Per QvistDepartment of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Séverine KunzTechnology Platform for Electron Microscopy, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.
Thomas ConradGenomics Technology Platform, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 10115 Berlin, Germany.
Thomas E WillnowMolecular Cardiovascular Research, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.
Vanessa SchmidtMolecular Cardiovascular Research, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.
Max Delbrück Center · DEAarhus University · DKCharité - Universitätsmedizin Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sorting receptor SORCS2 is a stress-response factor protecting neurons from acute insults, such as during epilepsy. SORCS2 is also expressed in the pancreas, yet its action in this tissue remains unknown. Combining metabolic studies in SORCS2-deficient mice with

Indexed as

Biological sciencesEndocrinologyNatural sciencesPhysiology

Identifiers

PMID38226160
PMCPMC10788290
OpenAlexW4389670836

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.