ArticleJournal of diabetes2024
Estimated glucose disposal rate predicts the risk of diabetic peripheral neuropathy in type 2 diabetes: A 5-year follow-up study.
Article in Journal of diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The role of estimated glucose disposal rate in predicting cardiovascular risk among general and diabetes mellitus population: a systematic review and meta-analysis.BMC medicine · 2025Pooled it
- Association between estimated glucose disposal rate and sarcopenia in U.S. adults: a cross-sectional study based on NHANES 2011-2018.Diabetology & metabolic syndrome · 2026Article
- Association between estimated glucose disposal rate and cognitive impairment in elderly patients with type 2 diabetes mellitus: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Association Between Estimated Glucose Disposal Rate and Chronic Kidney Disease in Elderly Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study in Zhejiang, China.Clinical interventions in aging · 2026Article
- Associations between estimated glucose disposal rate and hyperuricemia in patients with type 2 diabetes mellitus: a cross-sectional study.BMC nephrology · 2025Article
- Age Stratified Analyses of TyG Index eGDR and Additive Effects on T2DM Outcomes in Prevalence and Mortality.Scientific reports · 2025Article
- Joint effects of triglyceride glucose index and its obesity-related derivatives with estimated glucose disposal rate on cardiometabolic multimorbidity in middle-aged and older Chinese adults: a nationwide cohort study.Cardiovascular diabetology · 2025Article
- Association between estimated glucose disposal rate and heart failure in patients with diabetes or prediabetes: a cross-sectional study.BMC public health · 2025Article
- More comprehensive relationship between eGDR and sarcopenia in China: a nationwide cohort study with national representation.Diabetology & metabolic syndrome · 2025Article
- Association between estimated glucose disposal rate with the all-cause and cause-specific mortality among the population with cardiometabolic syndrome.Diabetology & metabolic syndrome · 2025Article
- Sarcopenia and Insulin Resistance Collective Effect on Atrial Fibrillation Risk: A Non-Diabetic Elderly Cohort Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Sex-specific associations between estimated glucose disposal rate and cognitive decline in middle-aged and older adults in China: a longitudinal cohort study.Frontiers in aging neuroscience · 2025Article
- Association between estimated glucose disposal rate and prediabetes reversion and progression: a nationwide cohort study of middle-aged and elderly people in China.Frontiers in endocrinology · 2025Article
- Discovery of Glucose Metabolism-Associated Genes in Neuropathic Pain: Insights from Bioinformatics.International journal of molecular sciences · 2024Article
- Estimated glucose disposal rate predicts the risk of diabetic peripheral neuropathy in type 2 diabetes: A 5-year follow-up study.Journal of diabetes · 2024Article
- Analyzing the impact of glycemic metabolic status on cardiovascular mortality and all-cause mortality related to the estimated glucose disposal rate: a nationwide cohort study.Frontiers in endocrinology · 2024Article
- Association between estimated glucose disposal rate and female infertility: a cross-sectional study.Frontiers in endocrinology · 2024Article
- Evaluation of Estimated Glucose Disposal Rate with Neutrophil-to-Lymphocyte Ratio Integrated for Prognosticating Adverse Cardiovascular and Cerebrovascular Events and Risk Stratification Among Acute Coronary Syndrome with Type 2 Diabetes Mellitus Following Percutaneous Coronary Intervention.Journal of inflammation research · 2024Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundInsulin resistance is associated with chronic complications of diabetes, including diabetic peripheral neuropathy (DPN). Estimated glucose disposal rate (eGDR), calculated by the common available clinical factors, was proved to be an excellent tool to measure insulin resistance in large patient population. Few studies have explored the association between eGDR and DPN longitudinally. Therefore, we performed the current study to analyze whether eGDR could predict the risk of DPN.
methodsIn this prospective study, 366 type 2 diabetes (T2DM) subjects without DPN were enrolled from six communities in Shanghai in 2011-2014 and followed up until 2019-2020. Neuropathy was assessed by Michigan Neuropathy Screening Instrument (MSNI) at baseline and at the end of follow-up.
findingsAfter 5.91 years, 198 of 366 participants progressed to DPN according to MNSI examination scores. The incidence of DPN in the low baseline eGDR (eGDR < 9.15) group was significantly higher than in the high baseline eGDR (eGDR ≥ 9.15) group (62.37% vs. 45.56%, p = .0013). The incidence of DPN was significantly higher in patients with sustained lower eGDR level (63.69%) compared with those with sustained higher eGDR level (35.80%). Subjects with low baseline eGDR (eGDR < 9.15) had significantly higher risk of DPN at the end of follow-up (odds ratio = 1.75), even after adjusting for other known DPN risk factors.
conclusionsThe 5-year follow-up study highlights the importance of insulin resistance represented by eGDR in the development of DPN in T2DM. Diabetic patients with low eGDR are more prone to DPN and, therefore, require more intensive screening and more attention.
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