Evidence map›Paper›PMID 38225693›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Nanoscale Metal-Organic Frameworks-Mediated Degradation of Mutant p53 Proteins and Activation of cGAS-STING Pathway for Enhanced Cancer Immunotherapy.

Li Sun, Hongbo Gao, Han Wang, Jingwei Zhou, Xiuru Ji, Yuxin Jiao, Xiaojia Qin, Dalong Ni, Xiangpeng Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

  1. ZIF-8 nanoplatform coordinating ZnInternational journal of pharmaceutics: X · 2026
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  10. Progress and prospects of metal-based immunotherapy in breast cancer.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Li SunDepartment of Radiation Oncology, Huadong Hospital, Fudan University, Shanghai, 200040, P. R. China.
Hongbo GaoDepartment of Radiation Oncology, Huadong Hospital, Fudan University, Shanghai, 200040, P. R. China.
Han WangDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P. R. China.ORCID 0000-0002-4086-5928
Jingwei ZhouDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, P. R. China.
Xiuru JiDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P. R. China.
Yuxin JiaoDepartment of Radiation Oncology, Huadong Hospital, Fudan University, Shanghai, 200040, P. R. China.
Xiaojia QinDepartment of Radiation Oncology, Huadong Hospital, Fudan University, Shanghai, 200040, P. R. China.
Dalong NiDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P. R. China.ORCID 0000-0001-6679-5414
Xiangpeng ZhengDepartment of Radiation Oncology, Huadong Hospital, Fudan University, Shanghai, 200040, P. R. China.
Fudan University · CNShanghai Jiao Tong University · CN

Funding

National Natural Science Foundation of China 82102190National Natural Science Foundation of China 82372098Opening Project of State Key Laboratory of High Performance Ceramics and Superfine Microstructure SKL202212SICShanghai Municipal Health Commission 2022JC006Shanghai Sailing Program 21YF1411500
6 · The paper itself

Abstract

Activating cGAS-STING pathway has great potential to achieve effective antitumor immunotherapy. However, mutant p53 (mutp53), a commonly observed genetic alteration in over 50% of human cancer, will impede the therapeutic performance of the cGAS-STING pathway. Herein, multifunctional ZIF-8@MnO

Indexed as

Metal-Organic FrameworksNeoplasmsHumansImmunotherapyManganese CompoundsOxidesTumor Suppressor Protein p53Manganese CompoundsMetal-Organic FrameworksOxidesTumor Suppressor Protein p53aPD‐L1cGAS‐STINGimmunotherapymetal–organic frameworksmutant p53proteasomal degradation

Identifiers

PMID38225693
PMCPMC10966556
OpenAlexW4390917322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.