ArticleBMC musculoskeletal disorders2024
Regional disparities, age-related changes and sex-related differences in knee osteoarthritis.
Article in BMC musculoskeletal disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Efficacy of aerobic exercises for knee osteoarthritis: a network meta analysis of randomized clinical trials.Journal of orthopaedic surgery and research · 2025Pooled it
- Pooled it
- Frequency-Dependent Effects of Warm Needle Acupuncture in Patients With Knee Osteoarthritis With Cold-Dampness Obstruction Syndrome: A Randomized Controlled Trial.Pain research & management · 2026Trial
- Dual regulation of inflammation and ferroptosis: An injectable hydrogel targeting macrophages for the treatment of temporomandibular joint osteoarthritis and knee osteoarthritis.Materials today. Bio · 2026Article
- Radiographic Analysis of Lower Limb Alignment in Patients with Knee Osteoarthritis.Tomography (Ann Arbor, Mich.) · 2026Article
- Clinical efficacy of arthroscopic microfracture combined with sodium hyaluronate in the treatment of knee osteoarthritis.American journal of translational research · 2026Article
- Global Burden of Hip and Knee Osteoarthritis Attributable to Metabolic Risks in Women of Reproductive Age, 1990-2021: A Systematic Analysis from the Global Burden of Disease Study 2021.International journal of women's health · 2026Article
- Global prevalence, incidence, and years lived with disability (YLDs) of osteoarthritis: trends from 1990 to 2021 and projections to 2050.Journal of orthopaedic translation · 2026Article
- Article
- Impact of Wiberg patellar morphology on patient-reported outcomes following unicompartmental knee arthroplasty: A 3 ~ 5 year retrospective cohort analysis.BMC musculoskeletal disorders · 2025Article
- Prevalence of radiographic knee osteoarthritis in China: a national survey of thirty thousand, four hundred and fifty five individuals cross-sectional study.International orthopaedics · 2025Article
- Unequal disease burdens: exploring the intersection of gender, health and disease dynamics in China.BMC public health · 2025Article
- Sex differences in intra-articular treatment outcomes for knee osteoarthritis: Current evidence and research gaps: A systematic review and meta-analysis.Journal of experimental orthopaedics · 2025Article
- Sex Differences in Obesity and Its Treatment.Current psychiatry reports · 2025Review
- The global burden of osteoarthritis knee: a secondary data analysis of a population-based study.Clinical rheumatology · 2025Article
- Article
- Article
- Effect of diabetes mellitus on physical function in patients with osteoarthritis: a cross-sectional observational study.Frontiers in endocrinology · 2025Observational
- The status and hotspot analysis of research on extracellular vesicles and osteoarthritis: a bibliometric analysis.Frontiers in pharmacology · 2025Review
- Burden of knee osteoarthritis in China and globally from 1992 to 2021, and projections to 2030: a systematic analysis from the Global Burden of Disease Study 2021.Frontiers in public health · 2025Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe objective of the study is to analyse the regions, age and sex differences in the incidence of knee osteoarthritis (KOA).
methodsData were extracted from the global burden of diseases (GBD) 2019 study, including incidence, years lived with disability (YLD), disability-adjusted life-years (DALYs) and risk factors. Estimated annual percentage changes (EAPCs) were calculated to quantify the temporal trends in age standardized rate (ASR) of KOA. Paired t-test, paired Wilcoxon signed-rank test and spearman correlation were performed to analyze the association of sex disparity in KOA and socio-demographic index (SDI).
resultsThere were significant regional differences in the incidence of knee osteoarthritis. In 2019, South Korea had the highest incidence of knee osteoarthritis (474.85,95%UI:413.34-539.64) and Thailand had the highest increase in incidence of knee osteoarthritis (EAPC = 0.56, 95%CI = 0.54-0.58). Notably, higher incidence, YLD and DALYs of knee osteoarthritis were associated with areas with a high socio-demographic index (r = 0.336, p < 0.001; r = 0.324, p < 0.001; r = 0.324, p < 0.001). In terms of age differences, the greatest increase in the incidence of knee osteoarthritis was between the 35-39 and 40-44 age groups. (EAPC = 0.52, 95%CI = 0.40-0.63; 0.47, 95%CI = 0.36-0.58). In addition, there were significant sex differences in the disease burden of knee osteoarthritis (P < 0.001).
conclusionsThe incidence of knee osteoarthritis is significantly different with regions, age and sex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.