ArticleBMC public health2024
Association of long-term exposure to various ambient air pollutants, lifestyle, and genetic predisposition with incident cognitive impairment and dementia.
Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- The association between air pollution and cognitive impairment: a systematic review and meta- analysis of global studies.BMC public health · 2025Pooled it
- Effect of air pollutants particulate matter (PMScientific reports · 2024Pooled it
- Associations of long-term exposure to source-specific PMEuropean archives of psychiatry and clinical neuroscience · 2026Article
- UK Biobank at 20 - a growing, global resource for dementia research.Nature reviews. Neurology · 2026Review
- Air Pollution and Alzheimer's Disease: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Interaction between air pollution and diet on cognitive function in schoolchildren.BMC public health · 2026Article
- Dissecting the effect of long-term exposure to air pollution on risk of dementia in UK Biobank.Environmental health : a global access science source · 2025Article
- Protective Role of Multiple Essential Minerals Against Cadmium-Related Cognitive Decline in Middle-Aged and Older Adults: A Prospective Study.Nutrients · 2025Article
- The absolute and relative concentration-response patterns of exposure to ambient air pollutants and the risk of Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2025Article
- Effects of air pollution and noise exposure on occupational hearing loss in oil workers: a prospective cohort study.BMC public health · 2025Article
- Methodological Considerations in the Study of Preserved-Ratio Impaired Spirometry and Dementia Risk.American journal of respiratory and critical care medicine · 2025Article
- The impact of environmental conditions on lifestyle quality in industrial and non-industrial region in the Czech Republic.Frontiers in public health · 2025Article
- Mechanistic insights regarding neuropsychiatric and neuropathologic impacts of air pollution.Critical reviews in toxicology · 2024Review
- Air Pollution as an Environmental Risk Factor for Alzheimer's Disease and Related Dementias.Medical research archives · 2024Article
- Integrating planetary health education into tertiary curricula: a practical toolbox for implementation.Frontiers in medicine · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLong-term exposure to air pollution has been found to contribute to the development of cognitive decline. Our study aimed to assess the association between various air pollutants and cognitive impairment and dementia. Additionally, explore the modification effects of lifestyle and genetic predisposition.
methodsThe exposure levels to various air pollutants, including particulate matter (PM) with diameters ≤ 2.5 (PM
resultsThe combined exposure to air pollutants was associated with an increased risk of incident cognitive decline. Compared with the low exposure group, the hazard ratio (HR) and 95% confidence interval (CI) for all-cause dementia, Alzheimer's dementia, vascular dementia, and mild cognitive impairment (MCI) in those exposed to the highest levels of air pollutants were respectively 1.07 (95% CI: 1.04 to 1.09), 1.08 (95% CI: 1.04 to 1.12), 1.07 (95% CI: 1.02 to 1.13), and 1.19 (95% CI: 1.12 to 1.27). However, the modification effects from genetic predisposition were not widely observed, while on the contrary for the healthy lifestyle. Our findings were proven to be reliable and robust based on the results of sensitivity analyses.
conclusionsExposure to air pollution was found to be a significant contributing factor to cognitive impairment and dementia, and this association was not easily modified by an individual's genetic predisposition. However, adopting a healthy lifestyle may help to manage the risk of cognitive decline related to air pollution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.