ArticleBMC neurology2024
Don't be late! Postponing cognitive decline and preventing early unemployment in people with multiple sclerosis: a study protocol.
Article in BMC neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06068582 (Don't be Late! Postponing Cognitive Decline and Preventing Early Unemployment in People With Multiple Sclerosis), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Don't be Late! Postponing Cognitive Decline and Preventing Early Unemployment in People With Multiple Sclerosis
Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- What Predicts Changes in the Work Situation of Recently Diagnosed People with Multiple Sclerosis and do these Predictors also Apply to Healthy People?Journal of occupational rehabilitation · 2026Article
- Application of Deep Multi-Scale Representation Learning Based on Eye-Tracking and Facial Expression Data in Cognitive Decline Assessment.Sensors (Basel, Switzerland) · 2026Article
- Vocational rehabilitation for people with multiple sclerosis: A systematic scoping review of international evidence.PloS one · 2026Article
- Cognitive awareness in people with multiple sclerosis before and after neuropsychological assessment.Journal of neurology · 2025Observational
- Exercise and Cognition in Multiple Sclerosis in 2025: Forward Momentum or Going Nowhere Fast?Current neurology and neuroscience reports · 2025Review
- Demystifying the New Dilemma of Brain Rot in the Digital Era: A Review.Brain sciences · 2025Review
- Article
- Impact of neuromyelitis optica spectrum disorder on employment and income in the United States.Annals of clinical and translational neurology · 2024Article
- Don't be late! Timely identification of cognitive impairment in people with multiple sclerosis: a study protocol.BMC neurology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundUp to 65% of people with multiple sclerosis (PwMS) develop cognitive deficits, which hampers their ability to work, participating in day-to-day life and ultimately reducing quality of life (QoL). Early cognitive symptoms are often less tangible to PwMS and their direct environment and are noticed only when symptoms and work functioning problems become more advanced, i.e., when (brain) damage is already advanced. Treatment of symptoms at a late stage can lead to cognitive impairment and unemployment, highlighting the need for preventative interventions in PwMS.
aimsThis study aims to evaluate the (cost-) effectiveness of two innovative preventative interventions, aimed at postponing cognitive decline and work functioning problems, compared to enhanced usual care in improving health-related QoL (HRQoL).
methodsRandomised controlled trial including 270 PwMS with mild cognitive impairment, who have paid employment ≥ 12 h per week and are able to participate in physical exercise (Expanded Disability Status Scale < 6.0). Participants are randomised across three study arms: 1) 'strengthening the brain' - a lifestyle intervention combining personal fitness, mental coaching, dietary advice, and cognitive training; 2) 'strengthening the mind' - a work-focused intervention combining the capability approach and the participatory approach in one-on-one coaching by trained work coaches who have MS themselves; 3) Control group-receiving general information about cognitive impairment in MS and receiving care as usual. Intervention duration is four months, with short-term and long-term follow-up measurements at 10 and 16 months, respectively. The primary outcome measure of the Don't be late! intervention study will be HRQoL as measured with the 36-item Short Form. Secondary outcomes include cognition, work related outcomes, physical functioning, structural and functional brain changes, psychological functioning, and societal costs. Semi-structured interviews and focus groups with stakeholders will be organised to qualitatively reflect on the process and outcome of the interventions. DISCUSSION: This study seeks to prevent (further) cognitive decline and job loss due to MS by introducing tailor-made interventions at an early stage of cognitive symptoms, thereby maintaining or improving HRQoL. Qualitative analyses will be performed to allow successful implementation into clinical practice.
trial registrationRetrospectively registered at ClinicalTrials.gov with reference number NCT06068582 on 10 October 2023.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.