Evidence map›Paper›PMID 38225526›Full record

ArticleNatural products and bioprospecting2024

Interaction mechanism between luteoloside and corn silk glycans and the synergistic role in hypoglycemic activity.

Shihui Qin, Yanlang Li, Huiyan Shao, Yang Yu, Yina Yang, Yi Zeng, Jia Huang, Jiang-Miao Hu, Liu Yang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Natural products and bioprospecting, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Shihui Qin *College of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, 230012, China.ORCID http://orcid.org/0000-0001-8504-5678
Yanlang Li *State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
Huiyan ShaoState Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
Yang YuCollege of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, 230012, China.
Yina YangCollege of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, 230012, China.
Yi ZengCollege of Pharmacy, Anhui University of Chinese Medicine, Hefei, Anhui, 230012, China.
Jia HuangState Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
Jiang-Miao HuState Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, 650201, China. hujiangmiao@mail.kib.ac.cn.
Liu YangState Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau, 999078, China. yangliu@mail.kib.ac.cn.
Kunming Institute of Botany · CNAnhui University of Traditional Chinese Medicine · CNMacau University of Science and Technology · MO

Funding

Chinese Academy of Sciences KFJ-BRP-007-019
6 · The paper itself

Abstract

As the two most principal active substances in the corn silk, polysaccharides and flavonoids, the mechanism of interaction between them has been a topic of intense research. This study provides an in-depth investigation of the interaction mechanism between corn silk glycans and luteoloside (LUT) and the synergistic role that result from this interaction. The interaction mechanism was evaluated by isothermal titration calorimetry (ITC) and circular dichroism (CD), and the synergistic role was evaluated by the expression of glucose transporters (GLUT-1), insulin secretion and surface plasmon resonance (SPR). CD and ITC results indicated that the interaction between CSGs and LUT mainly driven by the Cotton effects, enthalpy and entropy-driven. This interaction precipitated the formation of complexes (CSGs/LUT complexes) between corn silk glycans (CSGs) with four different molecular weights and luteoloside (LUT). Furthermore, the CSGs and LUT play a synergistic role in glucose regulation through GLUT-1 expression and insulin secretion experiments, compared to single luteoloside group.

Indexed as

Corn silk glycansCSGs/LUT complexesThe molecular interaction mechanismThe synergistic role

Identifiers

PMID38225526
PMCPMC10789705
OpenAlexW4390907446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.