Evidence map›Paper›PMID 38225480›Full record

ArticleGeroScience2024

Frontal-temporal regional differences in brain energy metabolism and mitochondrial function using

Francesca V Lopez, Andrew O'Shea, Zhiguang Huo, Steven T DeKosky, Theodore P Trouard, Gene E Alexander, Adam J Woods, Dawn Bowers

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Francesca V LopezDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, PO Box 100165, Gainesville, FL, 32610, USA. flopez1@ufl.edu.ORCID 0000-0003-0875-7326
Andrew O'SheaCenter for Cognitive Aging and Memory, Evelyn F. McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Zhiguang HuoDepartment of Biostatistics, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA.
Steven T DeKoskyDepartment of Neurology, Fixel Center for Neurological Diseases, College of Medicine, and Evelyn F. McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Theodore P TrouardDepartment of Biomedical Engineering, College of Engineering, and Evelyn F. McKnight Brain Institute, University of Arizona and Alzheimer's Disease Consortium, Tucson, AZ, USA.
Gene E AlexanderDepartment of Psychology and Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA.
Adam J WoodsDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, PO Box 100165, Gainesville, FL, 32610, USA.
Dawn BowersDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, PO Box 100165, Gainesville, FL, 32610, USA.
University of Florida · USUniversity of Arizona · USUniversity of Florida Health · US

Funding

Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI Nicholas Ashton · 2021 to 2026
$24.9M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Stephen D Anton · 2007 to 2026
$22.8M
Revitalizing Cognition in Older Adults at Risk for Alzheimer's Disease with Near-Infrared Photobiomodulation: Diversity SupplementR01AG064587 · NIA · UNIVERSITY OF FLORIDA · PI ALEXANDER, GENE E, BOWERS, DAWN · 2019 to 2023
$4.0M
Interdisciplinary Training in Movement Disorders and NeurorestorationT32NS082168 · NINDS · UNIVERSITY OF FLORIDA · PI Melissa Jo Armstrong, David E Vaillancourt · 2015 to 2026
$2.8M
Advanced 3T for Structural and Functional Imaging at University of FloridaS10OD021726 · OD · UNIVERSITY OF FLORIDA · PI LONG, JOANNA R · 2017 to 2017
$2.0M
Cognitive Correlates of Mitochondrial Function in Older AdultsF31AG071264 · NIA · UNIVERSITY OF FLORIDA · PI LOPEZ, FRANCESCA VEANNA · 2021 to 2022
$61k
NIA NIH HHS F31 AG071264NIA NIH HHS F31AG071264NIA NIH HHS P30 AG072980NIA NIH HHS R01 AG064587NIA NIH HHS R01AG64587NIH HHS S10 OD021726NINDS NIH HHS T32 NS082168NINDS NIH HHS T32NS082168
6 · The paper itself

Abstract

Aging is a major risk for cognitive decline and transition to dementia. One well-known age-related change involves decreased brain efficiency and energy production, mediated in part by changes in mitochondrial function. Damaged or dysfunctional mitochondria have been implicated in the pathogenesis of age-related neurodegenerative conditions like Alzheimer's disease (AD). The aim of the current study was to investigate mitochondrial function over frontal and temporal regions in a sample of 70 cognitively normal older adults with subjective memory complaints and a first-degree family history of AD. We hypothesized cerebral mitochondrial function and energy metabolism would be greater in temporal as compared to frontal regions based on the high energy consumption in the temporal lobes (i.e., hippocampus). To test this hypothesis, we used phosphorous (

Indexed as

Alzheimer DiseaseBrainAgedEnergy MetabolismHumansMagnetic Resonance SpectroscopyPhospholipidsPhospholipidsAgingBrain energy metabolismMitochondriaPhosphorus magnetic resonance spectroscopy

Identifiers

PMID38225480
PMCPMC11009166
OpenAlexW4390893054

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.