Evidence map›Paper›PMID 38225477›Full record

ArticleAnnals of surgical oncology2024

The Association Between Intraoperative Compromised Intestinal Integrity and Postoperative Complications in Cancer Patients.

Sharon Hendriks, Monique G Huisman, Suzanne C Stokmans, Matthijs Plas, Hanneke van der Wal-Huisman, Barbara C van Munster, Anthony R Absalom, Gertrude J Nieuwenhuijs-Moeke, Geertruida H de Bock, Barbara L van Leeuwen and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Sharon HendriksDepartment of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. s.hendriks@umcg.nl.ORCID http://orcid.org/0000-0002-7551-1599
Monique G HuismanDepartment of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Suzanne C StokmansDepartment of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Matthijs PlasDepartment of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Hanneke van der Wal-HuismanDepartment of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Barbara C van MunsterDepartment of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Anthony R AbsalomDepartment of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Gertrude J Nieuwenhuijs-MoekeDepartment of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Geertruida H de BockDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Barbara L van LeeuwenDepartment of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jacco J de HaanDepartment of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
University Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBecause of perioperative splanchnic hypoperfusion, the gut wall becomes more permeable for intraluminal microbes to enter the splanchnic circulation, possibly contributing to development of complications. Hypoperfusion-related injured enterocytes release intestinal fatty acid binding protein (I-FABP) into plasma, which is used as proxy of intestinal integrity. This study investigates the occurrence of intestinal integrity loss during oncologic surgery, measured by I-FABP change. Secondary the relationship between compromised intestinal integrity, and related variables and complications were studied.

methodsPatients undergoing oncologic surgery from prospective cohort studies were included. Urine I-FABP samples were collected preoperatively (T0) and at wound closure (T1), and in a subgroup on Day 1 (D1) and Day 2 (D2) postoperatively. I-FABP dynamics were investigated and logistic regression analyses were performed to study the association between I-FABP levels and patient-related, surgical variables and complications.

resultsA total of 297 patients were included with median age of 70 years. Median I-FABP value increased from 80.0 pg/mL at T0 (interquartile range [IQR] 38.0-142.0) to 115 pg/mL at T1 (IQR 48.0-198.0) (p < 0.05). Age (odds ratio [OR] 1.05, 95% confidence interval [CI] 1.02-1.08) and anesthesia time (OR 1.13, 95% CI 1.02-1.25) were related to stronger I-FABP increase. When comparing I-FABP change in patients experiencing any complications versus no complications, relative I-FABP change at T1 was 145% of T0 (IQR 86-260) versus 113% (IQR 44-184) respectively (p < 0.05).

conclusionsA significant change in I-FABP levels was seen perioperatively indicating compromised intestinal integrity. Age and anesthesia time were related to higher I-FABP increase. In patients experiencing postoperative complications, a higher I-FABP increase was found.

Indexed as

IntestinesNeoplasmsAgedBiomarkersHumansPostoperative ComplicationsProspective StudiesBiomarkers

Identifiers

PMID38225477
PMCPMC10908644
OpenAlexW4390875823

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.