Evidence map›Paper›PMID 38225472›Full record

ReviewCurrent osteoporosis reports2024

Use of AI Language Engine ChatGPT 4.0 to Write a Scientific Review Article Examining the Intersection of Alzheimer's Disease and Bone.

Tyler J Margetts, Sonali J Karnik, Hannah S Wang, Lilian I Plotkin, Adrian L Oblak, Jill C Fehrenbacher, Melissa A Kacena, Alexandru Movila

Abstract readReview
In one paragraph

Review in Current osteoporosis reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. The Application of Flipped Classroom Integrated with ChatGPT in Improving Graduate Education on Choroidal Melanoma.Journal of cancer education : the official journal of the American Association for Cancer Education · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
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  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tyler J MargettsDepartment of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Sonali J KarnikDepartment of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Hannah S WangDepartment of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Lilian I PlotkinDepartment of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Adrian L OblakDepartment of Radiology & Imaging Sciences, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Jill C FehrenbacherIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA.
Melissa A KacenaDepartment of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. mkacena@iupui.edu.
Alexandru MovilaIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA. amovila@iu.edu.

Funding

The IU/JAX Alzheimer's Disease Precision Models Center: Rat F344U54AG054345 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Gareth R Howell · 2016 to 2026
$95.6M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Angiogenic Therapy: Novel Approaches to Enhance Bone Regeneration in Aging - LOADR01AG060621 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI KACENA, MELISSA A, LI, JILIANG · 2019 to 2023
$3.7M
Short-Term Training Program In Biomedical SciencesT35HL110854 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Brittney-Shea Herbert, Catherine Rufatto Sears · 2012 to 2026
$3.4M
Impact of Acid Ceramidase Activity on MIF-mediated migration of circulating osteoclast precursors to periodontal bone lesions in relation to agingR01AG064003 · NIA · NOVA SOUTHEASTERN UNIVERSITY · PI MOVILA, ALEXANDRU · 2019 to 2022
$1.8M
Roles of Periodontal Bacteria-Derived Dihydroceramides in Alzheimer's Disease Exacerbated by Down SyndromeK02AG068595 · NIA · NOVA SOUTHEASTERN UNIVERSITY · PI MOVILA, ALEXANDRU · 2020 to 2024
$908k
Contribution of chromosome versus gonadal sex to bone mass and strengthR21AG078861 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI PLOTKIN, LILIAN IRENE · 2022 to 2023
$832k
Skeletal complications to a TREM2 variant associated with Alzheimer's DiseaseI01BX005154 · VA · RLR VA MEDICAL CENTER · PI PLOTKIN, LILIAN IRENE · 2021 to 2024
–
Impact of TPO Treatment on Bone Healing and Angiogenesis in Type 2 DiabetesI01BX003751 · VA · RLR VA MEDICAL CENTER · PI KACENA, MELISSA A · 2017 to 2021
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"Novel therapeutic approaches to improve fracture healing while reducing pain behavior"I01RX003552 · VA · RLR VA MEDICAL CENTER · PI KACENA, MELISSA A · 2022 to 2025
–
RR&D Research Career Scientist Award ApplicationIK6RX004809 · VA · RLR VA MEDICAL CENTER · PI KACENA, MELISSA A · 2023 to 2025
–
BLRD VA I01 BX003751BLRD VA I01 BX005154BLRD VA I01 BX006399NCATS NIH HHS UL1 TR002529NHLBI NIH HHS T35 HL110854NIA NIH HHS K02 AG068595NIA NIH HHS R01 AG060621NIA NIH HHS R01 AG064003NIA NIH HHS R21 AG078861NIA NIH HHS R56 AG064003NIH HHS AG060621-05S1/-05S2NIH HHS AG-064003NIH HHS AG078861/AG078861-S1NIH HHS T35HL110854NIH HHS U54AG054345RRD VA I01 RX003552RRD VA IK6 RX004809
6 · The paper itself

Abstract

purpose of reviewThis Comment represents three review articles on the relationship between Alzheimer's disease, osteoporosis, and fracture in an exploration of the benefits that AI can provide in scientific writing. The first drafts of the articles were written (1) entirely by humans; (2) entirely by ChatGPT 4.0 (AI-only or AIO); and (3) by humans and ChatGPT 4.0 whereby humans selected literature references, but ChatGPT 4.0 completed the writing (AI-assisted or AIA). Importantly, each review article was edited and carefully checked for accuracy by all co-authors resulting in a final manuscript which was significantly different from the original draft. RECENT

findingsThe human-written article took the most time from start to finish, the AI-only article took the least time, and the AI-assisted article fell between the two. When comparing first drafts to final drafts, the AI-only and AI-assisted articles had higher percentages of different text than the human article. The AI-only paper had a higher percentage of incorrect references in the first draft than the AI-assisted paper. The first draft of the AI-assisted article had a higher similarity score than the other two articles when examined by plagiarism identification software. This writing experiment used time tracking, human editing, and comparison software to examine the benefits and risks of using AI to assist in scientific writing. It showed that while AI may reduce total writing time, hallucinations and plagiarism were prevalent issues with this method and human editing was still necessary to ensure accuracy.

Indexed as

Alzheimer DiseaseFractures, BoneArtificial IntelligenceHumansLanguageWritingAIAlzheimer’s DiseaseArtificial intelligenceBone lossChatGPTFracturesOsteoporosisScientific writing

Identifiers

PMID38225472
PMCPMC10912103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.