ArticleMolecular psychiatry2024
Examining intergenerational risk factors for conduct problems using polygenic scores in the Norwegian Mother, Father and Child Cohort Study.
Article in Molecular psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Genetic investigation of the association between maternal dietary patterns and offspring ADHD.Molecular psychiatry · 2026Article
- The contribution of common and rare genetic variation to emotional and behavioural symptoms in childhood and adolescence.Molecular psychiatry · 2026Article
- Triangulating evidence for genetic and environmental components of associations between parental behaviours and aggressive behaviour in children.Nature communications · 2026Article
- Intra-familial dynamics of mental distress during the Covid-19 lockdown.Translational psychiatry · 2026Article
- Diet as a source of the non-direct genetic effects in metabolic traits: evidence from a family-based GWAS study.Human genetics · 2025Article
- In the genetics of the beholder: gene-environment interplay for internalising and externalising behaviours using polygenic scores and adolescent perceptions of parenting.European child & adolescent psychiatry · 2025Article
- Article
- Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development.Molecular psychiatry · 2025Article
- Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood.Nature communications · 2025Article
- Intergenerational transmission of genetic risk for hyperactivity and inattention. Direct genetic transmission or genetic nurture?JCPP advances · 2024Article
- Annual Research Review: Towards a deeper understanding of nature and nurture: combining family-based quasi-experimental methods with genomic data.Journal of child psychology and psychiatry, and allied disciplines · 2023Review
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
The aetiology of conduct problems involves a combination of genetic and environmental factors, many of which are inherently linked to parental characteristics given parents' central role in children's lives across development. It is important to disentangle to what extent links between parental heritable characteristics and children's behaviour are due to transmission of genetic risk or due to parental indirect genetic influences via the environment (i.e., genetic nurture). We used 31,290 genotyped mother-father-child trios from the Norwegian Mother, Father and Child Cohort Study (MoBa), testing genetic transmission and genetic nurture effects on conduct problems using 13 polygenic scores (PGS) spanning psychiatric conditions, substance use, education-related factors, and other risk factors. Maternal or self-reports of conduct problems at ages 8 and 14 years were available for up to 15,477 children. We found significant genetic transmission effects on conduct problems for 12 out of 13 PGS at age 8 years (strongest association: PGS for smoking, β = 0.07, 95% confidence interval = [0.05, 0.08]) and for 4 out of 13 PGS at age 14 years (strongest association: PGS for externalising problems, β = 0.08, 95% confidence interval = [0.05, 0.11]). Conversely, we did not find genetic nurture effects for conduct problems using our selection of PGS. Our findings provide evidence for genetic transmission in the association between parental characteristics and child conduct problems. Our results may also indicate that genetic nurture via traits indexed by our polygenic scores is of limited aetiological importance for conduct problems-though effects of small magnitude or effects via parental traits not captured by the included PGS remain a possibility.
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