ArticleCommunications biology2024
Muscle anatomy is reflected in the spatial organization of the spinal motoneuron pools.
Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Human iPSC-Derived Spinal Neurons Carrying the ALS FUS (P525L) Mutation Exhibit Lower Response to Inhibitory Neurotransmitters.Cellular and molecular neurobiology · 2026Article
- Comparative analyses of regional and temporal transcriptomics of early human and mouse central nervous systems.iScience · 2026Article
- From Fin to Limb: Orientational Shift and Evolution of Diagonal-Couplet Gait in Tetrapods.Integrative organismal biology (Oxford, England) · 2026Review
- Embodied sensorimotor control: computational modeling of the neural control of movement.ArXiv · 2025Article
- Effect of resistance training on kinetic and kinematic indicators in jump athletes: a systematic review.BMC sports science, medicine & rehabilitation · 2025Article
- Stroke-Related Changes in Tonic and Phasic Muscle Recruitment During Reaching Reveal Pathway-Specific Motor Deficits.Journal of central nervous system disease · 2025Article
- Nerve transfers improve upper limb function in children with acute flaccid myelitis.Brain & spine · 2025Article
- Control signal dimensionality depends on limb dynamics.PloS one · 2025Article
- Differential Impact of Biomechanical Constraints on Control Signal Dimensionality for Gravity Support Versus Propulsion.bioRxiv : the preprint server for biology · 2024Article
- Muscle anatomy is reflected in the spatial organization of the spinal motoneuron pools.Communications biology · 2024Article
- Spinal maps of motoneuron activity during human locomotion: neuromechanical considerations.Frontiers in physiology · 2024Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Neural circuits embed limb dynamics for motor control and sensorimotor integration. The somatotopic organization of motoneuron pools in the spinal cord may support these computations. Here, we tested if the spatial organization of motoneurons is related to the musculoskeletal anatomy. We created a 3D model of motoneuron locations within macaque spinal cord and compared the spatial distribution of motoneurons to the anatomical organization of the muscles they innervate. We demonstrated that the spatial distribution of motoneuron pools innervating the upper limb and the anatomical relationships between the muscles they innervate were similar between macaque and human species. Using comparative analysis, we found that the distances between motoneuron pools innervating synergistic muscles were the shortest, followed by those innervating antagonistic muscles. Such spatial organization can support the co-activation of synergistic muscles and reciprocal inhibition of antagonistic muscles. The spatial distribution of motoneurons may play an important role in embedding musculoskeletal dynamics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.