Evidence map›Paper›PMID 38225257›Full record

ArticleNature communications2024

Flexible switch matrix addressable electrode arrays with organic electrochemical transistor and pn diode technology.

Ilke Uguz, David Ohayon, Volkan Arslan, Rajendar Sheelamanthula, Sophie Griggs, Adel Hama, John William Stanton, Iain McCulloch, Sahika Inal, Kenneth L Shepard

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  5. Article
  6. Organic Electrochemical Transistors in Tissue-Interfaced Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  7. Article
  8. Review
  9. Multifunctional bioelectronics for brain-body circuits.Nature reviews bioengineering · 2025
    Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ilke UguzElectrical Engineering Department, Columbia University, New York, 10027, NY, USA. ilkeuguz@gmail.com.ORCID http://orcid.org/0000-0001-8898-876X
David OhayonOrganic Bioelectronics Laboratory, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.ORCID http://orcid.org/0000-0002-5564-9005
Volkan ArslanElectrical Engineering Department, Columbia University, New York, 10027, NY, USA.
Rajendar SheelamanthulaPhysical Science and Engineering Division, KAUST, Thuwal, 23955-6900, Saudi Arabia.
Sophie GriggsDepartment of Chemistry, University of Oxford, Oxford, OX1 3TA, UK.
Adel HamaOrganic Bioelectronics Laboratory, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.ORCID http://orcid.org/0000-0003-1926-181X
John William StantonElectrical Engineering Department, Columbia University, New York, 10027, NY, USA.ORCID http://orcid.org/0000-0001-9790-1240
Iain McCullochPhysical Science and Engineering Division, KAUST, Thuwal, 23955-6900, Saudi Arabia.ORCID http://orcid.org/0000-0002-6340-7217
Sahika InalOrganic Bioelectronics Laboratory, Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.ORCID http://orcid.org/0000-0002-1166-1512
Kenneth L ShepardElectrical Engineering Department, Columbia University, New York, 10027, NY, USA.ORCID http://orcid.org/0000-0003-0665-6775

Funding

Optimizing flexible, active electrode arrays for chronic, large-scale recording and stimulation on the scale of 100,000 electrodesU01NS099697 · NINDS · DUKE UNIVERSITY · PI BRAUN, PAUL, PESARAN, BIJAN · 2016 to 2018
$3.5M
Wide Deployment of Massively Multiplexed Nanosystems for Brain Activity MappingU01NS099726 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ROUKES, MICHAEL L, SHEPARD, KENNETH L · 2016 to 2018
$2.9M
NINDS NIH HHS U01 NS099697NINDS NIH HHS U01 NS099726
6 · The paper itself

Abstract

Due to their effective ionic-to-electronic signal conversion and mechanical flexibility, organic neural implants hold considerable promise for biocompatible neural interfaces. Current approaches are, however, primarily limited to passive electrodes due to a lack of circuit components to realize complex active circuits at the front-end. Here, we introduce a p-n organic electrochemical diode using complementary p- and n-type conducting polymer films embedded in a 15-μm -diameter vertical stack. Leveraging the efficient motion of encapsulated cations inside this polymer stack and the opposite doping mechanisms of the constituent polymers, we demonstrate high current rectification ratios ([Formula: see text]) and fast switching speeds (230 μs). We integrate p-n organic electrochemical diodes with organic electrochemical transistors in the front-end pixel of a recording array. This configuration facilitates the access of organic electrochemical transistor output currents within a large network operating in the same electrolyte, while minimizing crosstalk from neighboring elements due to minimized reverse-biased leakage. Furthermore, we use these devices to fabricate time-division-multiplexed amplifier arrays. Lastly, we show that, when fabricated in a shank format, this technology enables the multiplexing of amplified local field potentials directly in the active recording pixel (26-μm diameter) in a minimally invasive form factor with shank cross-sectional dimensions of only 50×8 [Formula: see text].

Identifiers

PMID38225257
PMCPMC10789794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.