Evidence map›Paper›PMID 38225244›Full record

ArticleNature communications2024

Dermatologist-like explainable AI enhances trust and confidence in diagnosing melanoma.

Tirtha Chanda, Katja Hauser, Sarah Hobelsberger, Tabea-Clara Bucher, Carina Nogueira Garcia, Christoph Wies, Harald Kittler, Philipp Tschandl, Cristian Navarrete-Dechent, Sebastian Podlipnik and 26 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
42.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. An interpretable multi-instance learning method for accurate differentiation of malignant and benign laryngeal lesions in laryngoscopy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  4. Beyond black-box AI: Comparing ChatGPT-4 interpretability and accuracy to CNNs in melanocytic lesions diagnosis.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Digital Dermatology.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2026
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Explainability in AI-enabled medical neurotechnology: a scoping review.Journal of neuroengineering and rehabilitation · 2026
    Article
  17. Review
  18. Review
  19. Review
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors at 20 institutions in 31 countries.

Tirtha Chanda *Digital Biomarkers for Oncology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0009-0009-0649-9301
Katja Hauser *Digital Biomarkers for Oncology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-9390-3505
Sarah Hobelsberger *Department of Dermatology, University Hospital, Technical University Dresden, Dresden, Germany.
Tabea-Clara BucherDigital Biomarkers for Oncology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-8157-5513
Carina Nogueira GarciaDigital Biomarkers for Oncology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-9092-5952
Christoph WiesDigital Biomarkers for Oncology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-7136-298X
Harald KittlerDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-0051-8016
Philipp TschandlDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-0391-7810
Cristian Navarrete-DechentDepartment of Dermatology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Sebastian PodlipnikDermatology Department, Hospital Clínic of Barcelona, University of Barcelona, IDIBAPS, Barcelona, Spain.ORCID 0000-0003-4150-0522
Emmanouil Chousakos1st Department of Pathology, Medical School, National & Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0002-8127-4761
Iva CrnaricDepartment of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
Jovana MajstorovicDerma Style, Dermatovenerology clinic, Belgrade, Serbia.ORCID 0009-0004-0980-7430
Linda AlhajwanDepartment of Dermatology, Dubai London Clinic, Dubai, United Arab Emirates.
Tanya ForemanWest Dermatology, Newport Beach, California, USA.
Sandra PeternelDepartment of Dermatovenereology, Clinical Hospital Center Rijeka, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.ORCID 0000-0001-8590-0451
Sergei SarapLaserMed, Tallinn, Estonia.
İrem ÖzdemirDepartment of Dermatology, Faculty of Medicine, Gazi University, Ankara, Turkey.ORCID 0000-0001-9764-4678
Raymond L BarnhillDepartment of Translational Research, Institut Curie, Unit of Formation and Research of Medicine University of Paris, Paris, France.
Mar Llamas-VelascoUniversidad Autónoma de Madrid, Madrid, Spain.
Gabriela PochCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Dermatology, Venereology and Allergology, Berlin, Germany.
Sören KorsingDepartment of Dermatology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Wiebke SondermannDepartment of Dermatology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-3684-3523
Frank Friedrich GellrichDepartment of Dermatology, University Hospital, Technical University Dresden, Dresden, Germany.ORCID 0000-0002-2164-4644
Markus V HepptDepartment of Dermatology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Michael ErdmannDepartment of Dermatology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0001-7136-6489
Sebastian HaferkampDepartment of Dermatology, University Hospital Regensburg, Regensburg, Germany.
Konstantin DrexlerDepartment of Dermatology, University Hospital Regensburg, Regensburg, Germany.
Matthias GoebelerDepartment of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.ORCID 0000-0001-7095-9848
Bastian SchillingDepartment of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.ORCID 0000-0001-8859-4103
Jochen S UtikalDepartment of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.ORCID 0000-0001-5316-0241
Kamran GhoreschiCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Dermatology, Venereology and Allergology, Berlin, Germany.ORCID 0000-0002-5526-7517
Stefan FröhlingDivision of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-7907-4595
Eva Krieghoff-HenningDigital Biomarkers for Oncology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Reader Study Consortium
Titus J BrinkerDigital Biomarkers for Oncology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. titus.brinker@dkfz.de.ORCID 0000-0002-3620-5919
German Cancer Research Center · DEUniversitätsklinikum Würzburg · DESs. Cyril and Methodius University in Skopje · MKCharité - Universitätsmedizin Berlin · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DETechnische Universität Dresden · DEUniversity Hospital Augsburg · DEUniversity Hospital of Zurich · CHEvangelismos Hospital · GRGhent University Hospital · BEHeidelberg University · DEKoç University · TRMedical University of Vienna · ATNorthwestern University · USParacelsus Medical University · ATPHI University Psychiatric Clinic - Skopje · MKRiga Stradiņš University · LVTechnical University of Munich · DEUniversität Hamburg · DEUniversity Children's Hospital Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artificial intelligence (AI) systems have been shown to help dermatologists diagnose melanoma more accurately, however they lack transparency, hindering user acceptance. Explainable AI (XAI) methods can help to increase transparency, yet often lack precise, domain-specific explanations. Moreover, the impact of XAI methods on dermatologists' decisions has not yet been evaluated. Building upon previous research, we introduce an XAI system that provides precise and domain-specific explanations alongside its differential diagnoses of melanomas and nevi. Through a three-phase study, we assess its impact on dermatologists' diagnostic accuracy, diagnostic confidence, and trust in the XAI-support. Our results show strong alignment between XAI and dermatologist explanations. We also show that dermatologists' confidence in their diagnoses, and their trust in the support system significantly increase with XAI compared to conventional AI. This study highlights dermatologists' willingness to adopt such XAI systems, promoting future use in the clinic.

Indexed as

MelanomaTrustArtificial IntelligenceDermatologistsDiagnosis, DifferentialHumans

Identifiers

PMID38225244
PMCPMC10789736
OpenAlexW4390879320

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.