ReviewTranslational psychiatry2024
Genetic differences associated with dopamine and serotonin release mediate fear-induced bradycardia in the human brain.
Review in Translational psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
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- Deteriorated Gray Matter Connectome in Diabetic Kidney Disease: A Graph Theory Analysis of Individual-Level Gray Matter Morphological Networks.Brain and behavior · 2025Article
- Unraveling functional neurological disorder in pediatric populations: A systematic review of diagnosis, treatment, and outcomes.World journal of clinical pediatrics · 2025Article
- Gut microbiota and the tryptophan-kynurenine pathway in anxiety: new insights and treatment strategies.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Druggable Targets for Postpartum Depression: A Mendelian Randomization and Colocalization Study.Cellular and molecular neurobiology · 2025Article
- Dualistic Dynamics in Neuropsychiatry: From Monoaminergic Modulators to Multiscale Biomarker Maps.Biomedicines · 2025Article
- Article
- Bibliometric Analysis of Neuroinflammation and Postoperative Cognitive Dysfunction.Brain and behavior · 2025Article
- Cortisol Imbalance and Fear Learning in PTSD: Therapeutic Approaches to Control Abnormal Fear Responses.Current neuropharmacology · 2025Review
- Mental automatism and exogenous psychosis: the originality of De Clérambault's and Karl Bonhoeffer's theories in substance-related psychoses.Frontiers in psychiatry · 2025Article
- Environmental Factors in the Etiology of Mental Disorders in the Czech Republic: Final Results.Neuropsychiatric disease and treatment · 2025Article
- Neuropsychobiology of fear-induced bradycardia in humans: progress and pitfalls.Molecular psychiatry · 2024Review
- Revolutionizing our understanding of Parkinson's disease: Dr. Heinz Reichmann's pioneering research and future research direction.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Redefining Roles: A Paradigm Shift in Tryptophan-Kynurenine Metabolism for Innovative Clinical Applications.International journal of molecular sciences · 2024Review
- Heart-Brain Axis: A Narrative Review of the Interaction between Depression and Arrhythmia.Biomedicines · 2024Review
- Article
- Rethinking Mental Automatism: De Clérambault's Theory in the Age of Novel Psychoactive Drugs: Psychotropic Effects and Synthetic Psychosis.Healthcare (Basel, Switzerland) · 2024Article
- The Involvement of Antioxidants in Cognitive Decline and Neurodegeneration:Antioxidants (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fear-induced bradycardia, a transient heartbeat deceleration following exposure to threat, is a physiological index observable in humans, especially in fear conditioning experiments. While gaining interest in recent years, it is still currently underemployed in neuroscientific research compared to more popular physiological indices. Besides its use in research, it could also constitute a valuable resource in a clinical psychiatry setting, as many disorders are also characterized by altered heart rate responses. However, differences in fear-induced bradycardia may also be subtended by genetic interindividual differences, thus suggesting precaution when recommending its use in the clinical setting. Here, we discussed the first endeavors that aimed at clarifying the genetic underpinnings of heart rate variations, which suggest that individual genetic differences have a role in defining the characteristics of heart rate responses. Given this, translating heart rate measurements in the clinical setting must be implemented with caution. Future endeavors in this field will aim at identifying these differences even further, thus allowing for more precise clinical interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.