ArticleHuman brain mapping2024
Cognition and motion dysfunction-associated brain functional network disruption in diabetic peripheral neuropathy.
Article in Human brain mapping, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Altered static and dynamic effective connectivity in patients with type 2 diabetes mellitus with and without microvascular complications.European journal of medical research · 2025Article
- Article
- Brain morphological changes in type 2 diabetes patients with painful peripheral neuropathy.Metabolic brain disease · 2025Article
- Cortical Surface Spatial Analysis Reveals Altered Brain Functional Network Topology in T2DM With Mild Cognitive Impairment.Brain and behavior · 2025Article
- Altered brain functional network connectivity and topology in type 2 diabetes mellitus.Frontiers in neuroscience · 2025Article
- Characterization of changes in the resting-state intrinsic network in patients with diabetic peripheral neuropathy.Scientific reports · 2024Article
- Cognition and motion dysfunction-associated brain functional network disruption in diabetic peripheral neuropathy.Human brain mapping · 2024Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Neuroimaging studies have demonstrated extensive brain functional alterations in cognitive and motor functional areas in Type 2 diabetes mellitus (T2DM) with diabetic peripheral neuropathy (DPN), suggesting potential alterations in large-scale brain networks related to DPN and associated cognition and motor dysfunction. In this study, using resting-state functional connectivity (FC) and graph theory computational approaches, we investigated the topological disruptions of brain functional networks in 28 DPN, 43 T2DM without DPN (NDPN), and 32 healthy controls (HCs) and examined the correlations between altered network topological metrics and cognitive/motor function parameters in T2DM. For global topology, NDPN exhibited a significantly decreased shortest path length compared with HCs, suggesting increased efficient global integration. For regional topology, DPN and NDPN had separated topological reorganization of functional hubs compared with HCs. In addition, DPN showed significantly decreased nodal efficiency (E
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.