Evidence map›Paper›PMID 38224394›Full record

ArticleApplied biochemistry and biotechnology2024

Treatment of Intracerebral Hemorrhage with Traditional Chinese Medicine Monomer Wogonin by Modifying NLRP3 with METTL14 to Inhibit Neuronal Cell Pyroptosis.

Libo Li, Jinbing Gong, Wenjia Zhang

Abstract read
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In one paragraph

Article in Applied biochemistry and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Libo LiNeurosurgery Department, The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, 95 Shaoshan Middle Road, Yuhua District, Changsha, 410007, China.
Jinbing GongNeurosurgery Department, The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, 95 Shaoshan Middle Road, Yuhua District, Changsha, 410007, China.
Wenjia ZhangNeurosurgery Department, The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, 95 Shaoshan Middle Road, Yuhua District, Changsha, 410007, China. zwenjia@hotmail.com.ORCID http://orcid.org/0009-0002-0261-9926

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to investigate the alleviating effect of wogonin on intracerebral hemorrhage (ICH) and its mechanism. The hemin-treated PC-12 cells were constructed to mimic ICH in vitro. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) analysis was used for cell viability measurement and flow cytometry was for pyroptosis detection. Enzyme-linked immunosorbent assay (ELISA) assay and western blot were used to detect the protein levels of pyroptosis-related proteins. The modification level of N6-methyladenosine (m

Indexed as

Cerebral HemorrhageFlavanonesMethyltransferasesNLR Family, Pyrin Domain-Containing 3 ProteinPyroptosisAnimalsDrugs, Chinese HerbalMaleMedicine, Chinese TraditionalMiceMice, Inbred C57BLMolecular Docking SimulationNeuronsPC12 CellsRatsDrugs, Chinese HerbalFlavanonesMethyltransferasesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratwogoninIntracerebral hemorrhagem6AMETTL14NLRP3Wogonin

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.