Evidence map›Paper›PMID 38224367›Full record

ArticleJournal of behavioral addictions2024

Genetics of gambling disorder and related phenotypes: The potential uses of polygenic and multifactorial risk models to enable early detection and improve clinical outcomes.

Varun Warrier, Samuel R Chamberlain, Shane A Thomas, Henrietta Bowden-Jones

Abstract read
In one paragraph

Article in Journal of behavioral addictions, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Varun Warrier1Department of Psychiatry, University of Cambridge, UK.ORCID 0000-0003-4532-8571
Samuel R Chamberlain2Department of Psychiatry, Faculty of Medicine, University of Southampton, Southern Health NHS Foundation Trust, Southampton, UK.ORCID 0000-0001-7014-8121
Shane A Thomas3Vice Chancellor's Office and Institute of Health and Wellbeing, Federation University, Australia.ORCID 0000-0003-3116-6022
Henrietta Bowden-Jones1Department of Psychiatry, University of Cambridge, UK.ORCID 0000-0002-9314-3697

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gambling Disorder (GD) is an impactful behavioural addiction for which there appear to be underpinning genetic contributors. Twin studies show significant GD heritability results and intergenerational transmission show high rates of transmission. Recent developments in polygenic and multifactorial risk prediction modelling provide promising opportunities to enable early identification and intervention for at risk individuals. People with GD often have significant delays in diagnosis and subsequent help-seeking that can compromise their recovery. In this paper we advocate for more research into the utility of polygenic and multifactorial risk modelling in GD research and treatment programs and rigorous evaluation of its costs and benefits.

Indexed as

Behavior, AddictiveGamblingHumansRisk Assessmentearly diagnosisearly interventionmultifactorial risk scorespolygenic risk scoresproblem gambling

Identifiers

PMID38224367
PMCPMC10988411

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.