Evidence map›Paper›PMID 38223978›Full record

ArticleCirculation2024

Epigenetic Regulation of Cardiomyocyte Maturation by Arginine Methyltransferase CARM1.

Tiffany A Garbutt, Zhenhua Wang, Haofei Wang, Hong Ma, Hongmei Ruan, Yanhan Dong, Yifang Xie, Lianmei Tan, Ranan Phookan, Joy A Stouffer and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Characterization of theFASEB bioAdvances · 2025
    Article
  10. PRMT3 and CARM1: Emerging Epigenetic Targets in Cancer.Journal of cellular and molecular medicine · 2025
    Review
  11. Molecular Regulation of Cardiomyocyte Maturation.Current cardiology reports · 2025
    Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tiffany A Garbutt *Department of Pathology and Laboratory Medicine (T.A.G., Z.W., H.W., H.M., Y.D., Y.X., L.T., R.P., J.A.S., Y.Y., L.Q., J.L.), University of North Carolina, Chapel Hill.ORCID 0000-0001-7134-5821
Zhenhua Wang *Department of Pathology and Laboratory Medicine (T.A.G., Z.W., H.W., H.M., Y.D., Y.X., L.T., R.P., J.A.S., Y.Y., L.Q., J.L.), University of North Carolina, Chapel Hill.
Haofei Wang *Department of Pathology and Laboratory Medicine (T.A.G., Z.W., H.W., H.M., Y.D., Y.X., L.T., R.P., J.A.S., Y.Y., L.Q., J.L.), University of North Carolina, Chapel Hill.ORCID 0000-0001-8914-442X
Hong MaDepartment of Pathology and Laboratory Medicine (T.A.G., Z.W., H.W., H.M., Y.D., Y.X., L.T., R.P., J.A.S., Y.Y., L.Q., J.L.), University of North Carolina, Chapel Hill.ORCID 0000-0003-3419-4627
Hongmei RuanDepartment of Medicine and Cardiovascular Research Institute, University of California, San Francisco (H.R., V.V.).
Yanhan DongDepartment of Pathology and Laboratory Medicine (T.A.G., Z.W., H.W., H.M., Y.D., Y.X., L.T., R.P., J.A.S., Y.Y., L.Q., J.L.), University of North Carolina, Chapel Hill.
Yifang XieDepartment of Pathology and Laboratory Medicine (T.A.G., Z.W., H.W., H.M., Y.D., Y.X., L.T., R.P., J.A.S., Y.Y., L.Q., J.L.), University of North Carolina, Chapel Hill.ORCID 0000-0002-5501-4018
Lianmei TanDepartment of Pathology and Laboratory Medicine (T.A.G., Z.W., H.W., H.M., Y.D., Y.X., L.T., R.P., J.A.S., Y.Y., L.Q., J.L.), University of North Carolina, Chapel Hill.
Ranan PhookanDepartment of Pathology and Laboratory Medicine (T.A.G., Z.W., H.W., H.M., Y.D., Y.X., L.T., R.P., J.A.S., Y.Y., L.Q., J.L.), University of North Carolina, Chapel Hill.
Joy A StoufferDepartment of Pathology and Laboratory Medicine (T.A.G., Z.W., H.W., H.M., Y.D., Y.X., L.T., R.P., J.A.S., Y.Y., L.Q., J.L.), University of North Carolina, Chapel Hill.
Vasanth VedanthamDepartment of Medicine and Cardiovascular Research Institute, University of California, San Francisco (H.R., V.V.).ORCID 0000-0003-1032-700X
Yuchen YangDepartment of Pathology and Laboratory Medicine (T.A.G., Z.W., H.W., H.M., Y.D., Y.X., L.T., R.P., J.A.S., Y.Y., L.Q., J.L.), University of North Carolina, Chapel Hill.ORCID 0000-0001-5977-1617
Li QianDepartment of Pathology and Laboratory Medicine (T.A.G., Z.W., H.W., H.M., Y.D., Y.X., L.T., R.P., J.A.S., Y.Y., L.Q., J.L.), University of North Carolina, Chapel Hill.ORCID 0000-0001-7614-5618
Jiandong LiuDepartment of Pathology and Laboratory Medicine (T.A.G., Z.W., H.W., H.M., Y.D., Y.X., L.T., R.P., J.A.S., Y.Y., L.Q., J.L.), University of North Carolina, Chapel Hill.ORCID 0000-0003-0035-3570

Funding

Altering Cardiac Cell Fate for Heart RepairR35HL155656 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Li Qian · 2021 to 2026
$5.5M
Macrophage functional dynamics in adult heart regenerationR01HL164933 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jiandong Liu · 2023 to 2026
$2.4M
A Regenerative Approach to Cardiac PacingDP2HL152425 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VEDANTHAM, VASANTH · 2019 to 2019
$2.4M
The role of RNA-binding protein Lin28a in hypertrophic cardiomyopathyR01HL139976 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, JIANDONG · 2019 to 2022
$2.1M
Molecular regulation of ventricular chamber maturationR01HL139880 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, JIANDONG · 2018 to 2022
$2.0M
American Heart Association-American Stroke Association 18TPA34180058NHLBI NIH HHS DP2 HL152425NHLBI NIH HHS R01 HL139880NHLBI NIH HHS R01 HL139976NHLBI NIH HHS R01 HL164933NHLBI NIH HHS R35 HL155656
6 · The paper itself

Abstract

backgroundDuring the neonatal stage, the cardiomyocyte undergoes a constellation of molecular, cytoarchitectural, and functional changes known collectively as cardiomyocyte maturation to increase myocardial contractility and cardiac output. Despite the importance of cardiomyocyte maturation, the molecular mechanisms governing this critical process remain largely unexplored.

methodsWe leveraged an in vivo mosaic knockout system to characterize the role of

resultsWe report that mosaic ablation of

conclusionsThis study establishes a critical and multifaceted role for CARM1 in regulating cardiomyocyte maturation and demonstrates that deregulation of CARM1-dependent cardiomyocyte maturation gene expression may contribute to human heart diseases.

Indexed as

Epigenesis, GeneticMyocytes, CardiacProtein-Arginine N-MethyltransferasesAnimalsCell DifferentiationHumansMiceMice, Knockoutcoactivator-associated arginine methyltransferase 1Protein-Arginine N-Methyltransferasescoactivator-associated arginine methyltransferase 1epigenomicsmyocytes, cardiacprotein-arginine N-methyltransferases

Identifiers

PMID38223978
PMCPMC11073921

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.