ArticleProceedings of SPIE--the International Society for Optical Engineering
Feasibility of Dual-Energy Cone-Beam CT of Bone Marrow Edema Using Dual-Layer Flat Panel Detectors.
Article in Proceedings of SPIE--the International Society for Optical Engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Scatter correction for contrast-enhanced digital breast tomosynthesis with a dual-layer detector.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Advantages of cone beam computed tomography for evaluation of subchondral insufficiency fractures of the knee compared to MRI.Scientific reports · 2024Article
- Review
- Quantitative Dual-Energy Imaging of Bone Marrow Edema Using Multisource Cone-Beam CT with Model-Based Decomposition.Proceedings of SPIE--the International Society for Optical Engineering · 2023Article
- Model-based three-material decomposition in dual-energy CT using the volume conservation constraint.Physics in medicine and biology · 2022Article
- Dual-Energy Cone-Beam CT with Three-Material Decomposition for Bone Marrow Edema Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Purpose: We investigated the feasibility of detection and quantification of bone marrow edema (BME) using dual-energy (DE) Cone-Beam CT (CBCT) with a dual-layer flat panel detector (FPD) and three-material decomposition. Methods: A realistic CBCT system simulator was applied to study the impact of detector quantization, scatter, and spectral calibration errors on the accuracy of fat-water-bone decompositions of dual-layer projections. The CBCT system featured 975 mm source-axis distance, 1,362 mm source-detector distance and a 430 × 430 mm Results: The decomposition is sensitive to scatter: approx. <20 mm collimation width or <10% error of scatter correction in a full field-of-view setting is needed to resolve BME. A mismatch in PDD decomposition calibration of ± 1 keV results in ~25% error in fat fraction estimates. In the wrist phantom study with MC scatter corrections, we were able to achieve ~0.79 mL true positive and ~0.06 mL false positive BME detection (compared to 0.85 mL true BME volume). Conclusions: Detection of BME using DE CBCT with dual-layer FPD is feasible, but requires scatter mitigation, accurate scatter estimation, and robust spectral calibration.
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Registered trials
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