Evidence map›Paper›PMID 38223763›Full record

ReviewPeerJ2024

Research insights into the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM): their roles in various tumors.

Sai-Li Duan, Yingke Jiang, Guo-Qing Li, Weijie Fu, Zewen Song, Li-Nan Li, Jia Li

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in PeerJ, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Research progress ofFrontiers in immunology · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sai-Li DuanDepartment of General Surgery, Xiangya Hospital Central South University, Changsha Province, Hunan, China.
Yingke JiangDepartment of General Surgery, Xiangya Hospital Central South University, Changsha Province, Hunan, China.ORCID 0000-0002-5763-7032
Guo-Qing LiXiangya School of Medicine, Central South University, Changsha Province, Hunan, China.
Weijie FuXiangya School of Medicine, Central South University, Changsha Province, Hunan, China.
Zewen SongDepartment of Oncology, The Third Xiangya Hospital of Central South University, Changsha Province, Hunan, China.
Li-Nan LiDepartment of Oncology, The 1st Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Jia LiDepartment of Oncology, The 1st Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Central South University · CNDalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing (CMTM) family includes CMTM1-8 and CKLF, and they play key roles in the hematopoietic, immune, cardiovascular, and male reproductive systems, participating in the physiological functions, cancer, and other diseases associated with these systems. CMTM family members activate and chemoattract immune cells to affect the proliferation and invasion of tumor cells through a similar mechanism, the structural characteristics typical of chemokines and transmembrane 4 superfamily (TM4SF). In this review, we discuss each CMTM family member's chromosomal location, involved signaling pathways, expression patterns, and potential roles, and mechanisms of action in pancreatic, breast, gastric and liver cancers. Furthermore, we discuss several clinically applied tumor therapies targeted at the CMTM family, indicating that CMTM family members could be novel immune checkpoints and potential targets effective in tumor treatment.

Indexed as

ChemokinesMARVEL Domain-Containing ProteinsNeoplasmsHumansSignal TransductionChemokinesCKLF protein, humanMARVEL Domain-Containing ProteinsApoptosis pathwayBreast cancerCMTM familyGastric cancerGene methylationLiver cancerPancreatic cancerProgrammed death-ligand 1

Identifiers

PMID38223763
PMCPMC10787544
OpenAlexW4390697398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.