ArticleToxicological research2024
Assessment of reproductive toxicity of gold nanoparticles and its reversibility in male albino rats.
Article in Toxicological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Assessment of Gold-Mediated Male Reproductive Dysfunction in Male WISTAR Rats Through Sperm Analysis and Testosterone Measurement.Journal of applied toxicology : JAT · 2026Article
- Application of 3D Cell Culture Techniques in Nanotoxicology: How Far Are We?Stem cell reviews and reports · 2026Review
- In vitro study of silver nanoparticles-induced embryotoxicity using a rat whole embryo culture model.Toxicological research · 2025Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanotechnology has become a trending area in science all over the world. Although gold nanoparticles (AuNPs) have been utilized widely in biomedical fields, potential toxicities may arise from their interactions with biological systems. The current study aimed at evaluating the toxic effects of AuNPs on the reproductive system of adult male albino rats and assessing the recovery probability. In this study, AuNPs (13 ± 4 nm in diameter) were synthesized, and the experimental work was conducted on 60 adult male albino rats divided into the following groups: control group (received deionized water daily intraperitoneally (IP) for 28 days), test group, and withdrawal groups I and II (received 570 μg/kg of 13 ± 4 nm AuNPs daily IP for 28 days). Withdrawal groups I and II were left for another 30 and 60 days without sacrification, respectively. The test group showed significant decreases in final body and absolute testicular weights, testosterone hormone level, sperm count and motility, and spermatogenesis score, as well as significant increase in the percentage of sperms of abnormal morphology compared to the control group, associated with significant light and electron microscopic histopathological changes. Partial improvement of all studied reproductive parameters was detected after one month of withdrawal in withdrawal group I, and significant improvement and reversibility of all these parameters were reported after two months of withdrawal in withdrawal group II. So, AuNPs induce male reproductive toxicity, which partially improves after one month of withdrawal and significantly improves and reverses after two months of withdrawal. Supplementary Information: The online version contains supplementary material available at 10.1007/s43188-023-00203-2.
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