Evidence map›Paper›PMID 38223421›Full record

ArticlePulmonary circulation2024

Impact of body position on hemodynamic measurements during exercise: A tale of two bikes.

Pradhab Kirupaharan, James Lane, Celia Melillo, Deborah Paul, Alla Amoushref, Sami Al Abdi, Adriano R Tonelli

Open access · goldAbstract read
In one paragraph

Article in Pulmonary circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Cardiac Output During Exercise: Thermodilution Versus Direct Fick.Journal of the American Heart Association · 2026
    Article
  3. Article
  4. Observational
  5. Article
  6. Article
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Pradhab KirupaharanDepartment of Pulmonary, Allergy, and Critical Care Medicine, Respiratory Institute Cleveland Clinic Cleveland Ohio USA.ORCID 0000-0002-0913-7092
James LaneDepartment of Pulmonary, Allergy, and Critical Care Medicine, Respiratory Institute Cleveland Clinic Cleveland Ohio USA.
Celia MelilloDepartment of Pulmonary, Allergy, and Critical Care Medicine, Respiratory Institute Cleveland Clinic Cleveland Ohio USA.
Deborah PaulDepartment of Pulmonary, Allergy, and Critical Care Medicine, Respiratory Institute Cleveland Clinic Cleveland Ohio USA.
Alla AmoushrefDepartment of Nephrology, Glickman Urological & Kidney Institute Cleveland Clinic Cleveland Ohio USA.
Sami Al AbdiDepartment of Internal Medicine Cleveland Clinic Fairview Hospital Fairview Ohio USA.
Adriano R TonelliDepartment of Pulmonary, Allergy, and Critical Care Medicine, Respiratory Institute Cleveland Clinic Cleveland Ohio USA.
Cleveland Clinic · USFairview Health Services · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The addition of exercise testing during right heart catheterization (RHC) is often required to accurately diagnose causes of exercise intolerance like early pulmonary vascular disease, occult left heart disease, and preload insufficiency. We tested the influence of body position (supine vs. seated) on hemodynamic classification both at rest and during exercise. We enrolled patients with exercise intolerance due to dyspnea who were referred for exercise RHC at the Cleveland Clinic. Patients were randomized (1:1) to exercise in seated or supine position to a goal of 60 W followed by maximal exercise in the alternate position. We analyzed 17 patients aged 60.3 ± 10.9 years, including 13 females. At rest in the sitting position, patients had significantly lower right atrial pressure (RAP), mean pulmonary artery pressure (mPAP), pulmonary artery wedge pressure (PAWP) and cardiac index (CI). In every stage of exercise (20, 40, and 60 W), the RAP, mPAP, and PAWP were lower in the sitting position. Exercise in the sitting position allowed the identification of preload insufficiency in nine patients. Exercise in either position increased the identification of postcapillary pulmonary hypertension (PH). Body position significantly influences hemodynamics at rest and with exercise; however, mPAP/CO and PAWP/CO were not positionally affected. Hemodynamic measurements in the seated position allowed the detection of preload insufficiency, a condition that was predominantly identified as no PH during supine exercise.

Indexed as

exercise hemodynamicsexercise intolerancepreload insufficiencypulmonary hypertensionright heart catheterization

Identifiers

PMID38223421
PMCPMC10784616
OpenAlexW4390816550

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.