Evidence map›Paper›PMID 38223338›Full record

ArticleClinical kidney journal2024

Real-world usage of Chronic Kidney Disease - Mineral Bone Disorder (CKD-MBD) biomarkers in nephrology practices.

Maria Fusaro, Simona Barbuto, Maurizio Gallieni, Althea Cossettini, Giulia Vanessa Re Sartò, Laura Cosmai, Giuseppe Cianciolo, Gaetano La Manna, Thomas Nickolas, Serge Ferrari and 15 more

Open access · goldAbstract read
In one paragraph

Article in Clinical kidney journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. A CombinedAnnals of biomedical engineering · 2026
    Article
  2. Review
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  4. High-potency statins are associated with reduced osteoporosis but increased fracture risk in CKD patients: a multi-center retrospective study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Observational
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  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 14 institutions in 4 countries.

Maria FusaroNational Research Council (CNR), Institute of Clinical Physiology (IFC), Pisa, Italy.ORCID https://orcid.org/0000-0001-9478-4851
Simona BarbutoNephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Maurizio GallieniDepartment of Biomedical and Clinical Sciences 'Luigi Sacco', Università di Milano, Milano, Italy.ORCID https://orcid.org/0000-0002-2011-2160
Althea CossettiniPost-Graduate School of Specialization in Nephrology, University of Milano, Milano, Italy.
Giulia Vanessa Re SartòPost-Graduate School of Specialization in Nephrology, University of Milano, Milano, Italy.
Laura CosmaiDivision of Nephrology and Dialysis, Azienda Socio-Sanitaria Territoriale (ASST) Fatebenefratelli-Sacco, Fatebenefratelli Hospital, Milan, Italy.ORCID https://orcid.org/0000-0002-9474-4232
Giuseppe CiancioloNephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Gaetano La MannaNephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Thomas NickolasDepartment of Medicine, Division of Nephrology, Columbia University, New York, NY, USA.ORCID https://orcid.org/0000-0001-8870-1896
Serge FerrariService des Maladies Osseuses, Département de Médecine, HUG, Geneva, Switzerland.ORCID https://orcid.org/0000-0002-1372-4417
Jordi BoverServicio de Nefrología, Hospital Universitario Germans Trias i Pujol, Badalona (Barcelona), Spain.
Mathias HaarhausDivision of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
Carmela MarinoNational Research Council (CNR), Institute of Clinical Physiology (IFC), Reggio Calabria, Italy.
Maria Cristina MereuIndependent Researcher, Cagliari, Italy.
Maura RaveraNephrology, Dialysis, and Transplantation, University of Genoa and Policlinico San Martino, 16132 Genoa, Italy.
Mario PlebaniLaboratory Medicine Unit, Department of Medicine, University of Padua, Padua, Italy.ORCID https://orcid.org/0000-0002-0270-1711
Martina ZaninottoLaboratory Medicine Unit, Department of Medicine, University of Padua, Padua, Italy.
Mario CozzolinoDepartment of Health Sciences, Renal Division, University of Milan, ASST Santi Paolo e Carlo, Milan, Italy.ORCID https://orcid.org/0000-0002-8494-6252
Stefano BianchiDepartment of Internal Medicine, Nephrology and Dialysis Complex Operative Unit, Livorno, Italy.
Piergiorgio MessaNephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID https://orcid.org/0000-0002-1512-559X
Mariacristina GregoriniSC Nefrologia e Dialisi AUSL-IRCCS Reggio Emilia, Reggio Emilia, Italy.
Lorenzo GasperoniNephrology and Dialysis Unit, Infermi Hospital, AUSL Romagna, Rimini, Italy.
Caterina AgostoPediatric Pain and Palliative Care Service, Department of Women's and Children's Health, Padua University Hospital, Padua, Italy.
Andrea AghiIndependent Researcher, Padua, Italy.
Giovanni TripepiNational Research Council (CNR), Institute of Clinical Physiology (IFC), Reggio Calabria, Italy.
University of Milan · ITUniversity of Padua · ITAzienda USL di Bologna · ITIstituto di Fisiologia Clinica · ITAzienda Sanitaria Unità Locale di Reggio Emilia · ITColumbia University · USFatebenefratelli Hospital · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITHospital Universitari Germans Trias i Pujol · ESKarolinska University Hospital · SEOspedale di Livorno · ITOspedale Infermi di Rimini · ITOspedale Policlinico San Martino · ITUniversity of Cagliari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic kidney disease mineral bone disorder (CKD-MBD) is a condition characterized by alterations of calcium, phosphate, parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF-23) metabolism that in turn promote bone disorders, vascular calcifications, and increase cardiovascular (CV) risk. Nephrologists' awareness of diagnostic, prognostic, and therapeutic tools to manage CKD-MBD plays a primary role in adequately preventing and managing this condition in clinical practice. Methods: A national survey (composed of 15 closed questions) was launched to inquire about the use of bone biomarkers in the management of CKD-MBD patients by nephrologists and to gain knowledge about the implementation of guideline recommendations in clinical practice. Results: One hundred and six Italian nephrologists participated in the survey for an overall response rate of about 10%. Nephrologists indicated that the laboratories of their hospitals were able to satisfy request of ionized calcium levels, 105 (99.1%) of both PTH and alkaline phosphatase (ALP), 100 (94.3%) of 25(OH)D, and 61 (57.5%) of 1.25(OH) Conclusion: Results point out a marked heterogeneity in the management of CKD-MBD by clinicians as well as a suboptimal implementation of guidelines in Italian clinical practice.

Indexed as

bone biomarkersbone fracturesbone turnover markersCKD-MBDvascular calcifications

Identifiers

PMID38223338
PMCPMC10784916
OpenAlexW4389202167

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.