Evidence map›Paper›PMID 38223200›Full record

ArticleFASEB bioAdvances2024

Toll-interacting protein inhibits transforming growth factor beta signaling in mouse lung fibroblasts.

Yu-Hua Chow, Cecilia López-Martínez, W Conrad Liles, William A Altemeier, Sina A Gharib, Chi F Hung

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB bioAdvances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 68% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yu-Hua ChowDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine University of Washington Seattle Washington USA.
Cecilia López-MartínezInstituto de Investigación Sanitaria del Principado de Asturias Oviedo Spain.
W Conrad LilesCenter for Lung Biology University of Washington Seattle Washington USA.
William A AltemeierDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine University of Washington Seattle Washington USA.
Sina A GharibDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine University of Washington Seattle Washington USA.
Chi F HungDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine University of Washington Seattle Washington USA.
Washington Center · USInstituto de Investigación Sanitaria del Principado de Asturias · ES

Funding

Functional diversity of lung pericytes in lung injuryR01HL166273 · NHLBI · UNIVERSITY OF WASHINGTON · PI Chi F Hung · 2023 to 2026
$2.5M
Application of single-cell trajectory analysis in single-cell transcriptomics to elucidate the biology of lung pericytes in injury, repair, and regenerationR03HL155075 · NHLBI · UNIVERSITY OF WASHINGTON · PI HUNG, CHI F · 2022 to 2023
$177k
NHLBI NIH HHS R01 HL166273NHLBI NIH HHS R03 HL155075
6 · The paper itself

Abstract

Variations in the Toll-interacting protein (TOLLIP) gene have been identified in genome-wide association studies to correlate with risk of disease, mortality, and response to N-acetylcysteine therapy in idiopathic pulmonary fibrosis. Although TOLLIP is known to modulate innate immune responses, its relevance in organ fibrogenesis remains unknown. Prior work in the literature suggests TOLLIP dampens transforming growth factor beta (TGFβ) signaling in human cell lines. In this study, we examined the role of TOLLIP in mouse lung fibroblast (MLF) responses to TGFβ and in the bleomycin model of experimental lung fibrosis using

Indexed as

bleomycinfibroblastslung injurymyofibroblastsTGFβToll‐interacting proteinTOLLIPtransforming growth factor beta

Identifiers

PMID38223200
PMCPMC10782472
OpenAlexW4389140325

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.