Evidence map›Paper›PMID 38223190›Full record

ArticleBiomedical optics express2024

Combined fluorescence lifetime and surface topographical imaging of biological tissue.

Charlotte Hopkinson, Andrew B Matheson, Neil Finlayson, Michael G Tanner, Ahsan R Akram, Robert K Henderson

Abstract read
In one paragraph

Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Charlotte HopkinsonInstitute for Integrated Micro and Nano Systems, School of Engineering, University of Edinburgh, Edinburgh EH9 3FF, UK.ORCID https://orcid.org/0000-0003-1836-0939
Andrew B MathesonInstitute for Integrated Micro and Nano Systems, School of Engineering, University of Edinburgh, Edinburgh EH9 3FF, UK.ORCID https://orcid.org/0000-0002-9391-6469
Neil FinlaysonInstitute for Integrated Micro and Nano Systems, School of Engineering, University of Edinburgh, Edinburgh EH9 3FF, UK.ORCID https://orcid.org/0000-0003-1598-9563
Michael G TannerInstitute of Photonics and Quantum Sciences, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK.ORCID https://orcid.org/0000-0001-7432-0312
Ahsan R AkramCentre for Inflammation Research, Institute of Regeneration and Repair, University of Edinburgh, Edinburgh BioQuarter, Edinburgh EH16 4UU, UK.
Robert K HendersonInstitute for Integrated Micro and Nano Systems, School of Engineering, University of Edinburgh, Edinburgh EH9 3FF, UK.ORCID https://orcid.org/0000-0002-0398-7520

Funding

Cancer Research UK 24867
6 · The paper itself

Abstract

In this work a combined fluorescence lifetime and surface topographical imaging system is demonstrated. Based around a 126 × 192 time resolved single photon avalanche diode (SPAD) array operating in time correlated single-photon counting (TCSPC) mode, both the fluorescence lifetime and time of flight (ToF) can be calculated on a pixel by pixel basis. Initial tests on fluorescent samples show it is able to provide 4 mm resolution in distance and 0.4 ns resolution in lifetime. This combined modality has potential biomedical applications such as surgical guidance, endoscopy, and diagnostic imaging. The system is demonstrated on both ovine and human pulmonary tissue samples, where it offers excellent fluorescence lifetime contrast whilst also giving a measure of the distance to the sample surface.

Identifiers

PMID38223190
PMCPMC10783922

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.