ArticleBiomedical optics express2024
Multi-resolution X-ray phase-contrast and dark-field tomography of human cerebellum with near-field speckles.
Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Comparing Laboratory and Synchrotron X-Ray CT for Structural Analysis of PEEK Orthopedic Implants.Biomimetics (Basel, Switzerland) · 2026Article
- Directional dark field for nanoscale full-field transmission X-ray microscopy.Light, science & applications · 2026Article
- Speckle-based X-ray microtomography via preconditioned Wirtinger flow.Light, science & applications · 2026Article
- Speckle-Based Transmission and Dark-Field Imaging for Material Analysis with a Laboratory X-Ray Source.Sensors (Basel, Switzerland) · 2025Article
- High-resolution X-ray phase-contrast tomography of human placenta with different wavefront markers.Scientific reports · 2025Article
- Exploring single-shot propagation and speckle based phase recovery techniques for object thickness estimation by using a polychromatic X-ray laboratory source.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Introduction to the Optics and the Brain 2023 feature issue.Biomedical optics express · 2024Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we use synchrotron-based multi-modal X-ray tomography to examine human cerebellar tissue in three dimensions at two levels of spatial resolution (2.3 µm and 11.9 µm). We show that speckle-based imaging (SBI) produces results that are comparable to propagation-based imaging (PBI), a well-established phase-sensitive imaging method. The different SBI signals provide complementary information, which improves tissue differentiation. In particular, the dark-field signal aids in distinguishing tissues with similar average electron density but different microstructural variations. The setup's high resolution and the imaging technique's excellent phase sensitivity enabled the identification of different cellular layers and additionally, different cell types within these layers. We also correlated this high-resolution phase-contrast information with measured dark-field signal levels. These findings demonstrate the viability of SBI and the potential benefit of the dark-field modality for virtual histology of brain tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.