ReviewCritical care explorations2024
Glycemic Variability As a Prognostic Factor for Mortality in Patients With Critical Illness: A Systematic Review and Meta-Analysis.
Review in Critical care explorations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Short-term glycemic variability and the risk of adverse ICU outcomes in critically ill patients: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Glycemic variability and the short-term mortality of hospitalized patients with COVID-19: a meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Evidence summary for optimal glycemic variability management during enteral nutrition in adult ICU patients with cerebral infarction.Frontiers in nutrition · 2026Pooled it
- Incremental Prognostic Value of Glucose Variability and the Lactate-to-Albumin Ratio Beyond APACHE II After a 48-Hour Landmark in Critically Ill Adults: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Blood Glucose Trajectories and Mortality in Sepsis-Induced Coagulopathy: A Latent Growth Mixture Modeling Analysis.Shock (Augusta, Ga.) · 2026Article
- How glycemic variability trajectories impact clinical outcomes in critically ill patients with severe pneumonia: a prospective cohort study.BMC anesthesiology · 2026Article
- Stress-hyperglycemia ratio and glycemic variability predict severity and mortality in sepsis-associated acute respiratory distress syndrome.World journal of emergency medicine · 2026Article
- Variability in Key Physiological Parameters in Neurocritical Stroke Patients: A Multicenter Observational Study.Journal of clinical medicine · 2026Article
- Association of triglyceride-glucose index fluctuation with in-hospital all-cause mortality in critically ill patients: a multidatabase retrospective study.Scientific reports · 2026Observational
- Association between sustained moderate hyperglycemia within first 48 hours and poor functional outcome after polytrauma: A retrospective cohort study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Observational
- Time-weighted lactate and glucose-lactate ratio outperform static values in ICU mortality prediction after traumatic brain injury: a retrospective cohort study.Journal of intensive care · 2026Article
- Hemoglobin glycation index and short-term mortality in sepsis: a retrospective cohort study with external validation.Frontiers in medicine · 2026Article
- Combined impact of glucose variability and mineral disorders on mortality and severe cardiorenal events in critically ill CKD patients: a multicenter cohort study.Frontiers in medicine · 2026Article
- Association Between the Lactate-to-Albumin Ratio and ICU/In-Hospital Mortality in Critically Ill Patients With Comorbid Type 2 Diabetes Mellitus : A Cohort Study Utilizing the MIMIC-IV Database.Emergency medicine international · 2026Article
- Accuracy and Clinical Safety of the FreeStyle Libre 2 System in an Internal Medicine Intermediate Care Unit.Cureus · 2026Article
- Association of glycemic variability with short- and long-term mortality in critically ill patients with trauma.Scientific reports · 2025Article
- Nonlinear relationship between mean amplitude of glycemic excursion and mortality in critically ill stroke patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Glycemic variability and postoperative mortality following cardiac surgery: evidence from a real-world ICU cohort.BMC cardiovascular disorders · 2025Observational
- Association between triglyceride-glucose index trajectories and in-hospital mortality in sepsis: a cohort study based on the MIMIC-IV database.Lipids in health and disease · 2025Article
- Association of the time in targeted blood glucose range of 140 to 180 mg/dL with the mortality of critically ill patients with diabetes: analysis of the MIMIC-IV database.Journal of clinical & translational endocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo perform a systematic review and meta-analysis to evaluate the association of various measures of glycemic variability, including time-domain and complexity-domain, with short-term mortality in patients with critical illness. DATA SOURCES: We searched Embase Classic +, MEDLINE, and the Cochrane Database of Systematic Reviews from inception to November 3, 2023. STUDY SELECTION: We included English language studies that assessed metrics of glycemic variation or complexity and short-term mortality in patients admitted to the ICU. DATA EXTRACTION: Two authors performed independent data abstraction and risk-of-bias assessments. We used a random-effects model to pool binary and continuous data and summarized estimates of effect using odds ratios and mean difference. We used the Quality in Prognosis Studies tool to assess risk of bias and the Grading of Recommendations, Assessment, Development and Evaluations to assess certainty of pooled estimates. DATA SYNTHESIS: We included 41 studies (
conclusionsWe found a consistent association between increased measures of glycemic variability and higher short-term mortality in patient with critical illness. Further research should focus on standardized measurements of glycemic variation and complexity, along with their utility as therapeutic targets and prognostic markers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.