Evidence map›Paper›PMID 38222827›Full record

ArticleCanada communicable disease report = Releve des maladies transmissibles au Canada2022

National Hepatitis C estimates: Incidence, prevalence, undiagnosed proportion and treatment, Canada, 2019.

Nashira Popovic, Anson Williams, Simone Périnet, Laurence Campeau, Qiuying Yang, Fan Zhang, Ping Yan, Jordan Feld, Naveed Janjua, Marina Klein and 3 more

Abstract read
In one paragraph

Article in Canada communicable disease report = Releve des maladies transmissibles au Canada, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Medication Utilization at a Provincial Remand Centre.The Canadian journal of hospital pharmacy · 2025
    Article
  15. Article
  16. Review
  17. Hepatitis C Screening in Community Pharmacies-A Feasibility and Knowledge Transfer Study: PHARMA-C.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nashira PopovicCentre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON.
Anson WilliamsCentre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON.
Simone PérinetCentre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON.
Laurence CampeauCentre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON.
Qiuying YangCentre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON.
Fan ZhangCentre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON.
Ping YanCentre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON.
Jordan FeldToronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, ON.
Naveed JanjuaBritish Columbia Centre for Disease Control, Vancouver, BC.
Marina KleinDepartment of Medicine, McGill University Health Center, Montréal, QC.
Mel KrajdenBritish Columbia Centre for Disease Control, Vancouver, BC.
William WongSchool of Pharmacy, University of Waterloo, Kitchener, ON.
Joseph CoxCentre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Estimates of the number of hepatitis C virus (HCV) infections are important for monitoring efforts aimed at preventing disease transmission, especially following the introduction of a highly effective treatment. This report provides updated estimates of HCV incidence, prevalence, undiagnosed proportion and treatment in Canada. Methods: A combination of back calculation modelling and a modified version of the workbook method were used to estimate the incidence and prevalence of anti-HCV positive persons, the prevalence of chronic HCV infection and the undiagnosed proportion. The number of people treated for chronic HCV was estimated using administrative pharmaceutical data. Results: An estimated 9,470 new infections occurred in 2019, corresponding to an incidence rate of 25 per 100,000 population, a 7.7% decrease since 2015. The estimated prevalence of anti-HCV antibodies in the Canadian population was 1.03% (plausible range: 0.83%-1.38%), and the estimated prevalence of chronic HCV was 0.54% (plausible range: 0.40%-0.79%). The overall proportion of anti-HCV positive persons who were undiagnosed was estimated at 24% of all infections, with individuals born between 1945 and 1975 being the priority population the most likely to be undiagnosed. An estimated 74,500 people with chronic HCV have been treated since the introduction of direct-acting antivirals in 2014. Conclusion: Estimates of HCV incidence and prevalence are key metrics to guide interventions and resource allocation. While our estimates show that HCV incidence has decreased in Canada in recent years and treatment of chronic HCV has continued to increase, ongoing efforts are required to reduce the burden of HCV in Canada.

Indexed as

CanadaepidemiologyHepatitis Cincidenceprevalence

Identifiers

PMID38222827
PMCPMC10786238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.