ArticleJOR spine2024
Thresholding approaches for estimating paraspinal muscle fat infiltration using T1- and T2-weighted MRI: Comparative analysis using water-fat MRI.
Article in JOR spine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Automatability and validity of methods for the quantification of intra-/Intermuscular adipose tissue in conventional MRI: a systematic review.BMC medical imaging · 2025Pooled it
- Early and persisting increase in fat content after human muscle strain injuries in adults.Physiological reports · 2026Article
- Lumbar Muscle Morphology Correlates With Early Surgical Outcomes in Adolescent Idiopathic Scoliosis: A Pilot Study.Global spine journal · 2026Article
- Spinal mobility and paraspinal muscle degeneration: a cross-sectional analysis from the Berlin Back Study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Asymmetry of muscle changes is most pronounced at the apex of degenerative lumbar scoliosis: a retrospective cross-sectional analysis of older adults.Spine deformity · 2026Article
- Lumbar muscle morphology and composition in adolescent idiopathic scoliosis: a magnetic resonance study.Spine deformity · 2026Article
- Clinical significance and future applications of standardized imaging parameters for assessing paraspinal muscle fatty infiltration in lumbar degenerative disease: a narrative review.Journal of orthopaedic surgery and research · 2026Review
- Deep learning-based assessment of paraspinal muscle degeneration and its relationships to muscle function and disability outcomes in chronic low back pain: a prospective study.European radiology · 2026Article
- Nonlinear Association Between Body Roundness Index and Axial Spinal Pain in Middle-Aged and Older Chinese Adults: A Nationwide Cross-Sectional Study.Pain research & management · 2026Article
- Semi-quantitative assessment of paraspinal muscle fat infiltration in single-level C5-6 cervical spondylosis using gray-level thresholding on conventional MRI: associations with disc degeneration and posture-related segmental angular change.Frontiers in medicine · 2026Article
- Myosteatosis: diagnostic significance and assessment by imaging approaches.Quantitative imaging in medicine and surgery · 2024Review
- Quantifying lumbar paraspinal intramuscular fat: Accuracy and reliability of automated thresholding models.North American Spine Society journal · 2024Article
- Article
- Artificial Intelligence in Spine and Paraspinal Muscle Analysis.Advances in experimental medicine and biology · 2024Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Background: Paraspinal muscle fat infiltration is associated with spinal degeneration and low back pain, however, quantifying muscle fat using clinical magnetic resonance imaging (MRI) techniques continues to be a challenge. Advanced MRI techniques, including chemical-shift encoding (CSE) based water-fat MRI, enable accurate measurement of muscle fat, but such techniques are not widely available in routine clinical practice. Methods: To facilitate assessment of paraspinal muscle fat using clinical imaging, we compared four thresholding approaches for estimating muscle fat fraction (FF) using T1- and T2-weighted images, with measurements from water-fat MRI as the ground truth: Gaussian thresholding, Otsu's method, K-mean clustering, and quadratic discriminant analysis. Pearson's correlation coefficients ( Results: We found that for all muscles combined, FF measurements from T1- and T2-weighted images were strongly positively correlated with measurements from the water-fat images for all thresholding techniques ( Conclusion: We conclude that muscle FF can be quantified using thresholded T1- and T2-weighted MRI images with relatively low bias and absolute error in relation to water-fat MRI, particularly in the MF and ES, and the choice of thresholding technique should depend on the muscle and clinical MRI sequence of interest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.