The apoptotic and anti-proliferative effect of Lysyl oxidase propeptide in Y79 human retinoblastoma cells.

Nareshkumar Ragavachetty Nagaraj, Sulochana Konerirajapuram Natarajan, Coral Karunakaran

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Article in Molecular vision, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 authors at 1 institution in 1 country.

Nareshkumar Ragavachetty NagarajRS Mehta Jain Department of Biochemistry and Cell biology, KBIRVO, Vision Research Foundation, Chennai.

Sulochana Konerirajapuram NatarajanRS Mehta Jain Department of Biochemistry and Cell biology, KBIRVO, Vision Research Foundation, Chennai.

Coral KarunakaranRS Mehta Jain Department of Biochemistry and Cell biology, KBIRVO, Vision Research Foundation, Chennai.

SASTRA University · IN

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6 · The paper itself

Abstract

Purpose: Retinoblastoma (RB) caused by the mutation of the Methods: LOX-PP was overexpressed in Y79 RB cells, and differential gene expression was assessed by microarray followed by pathway analysis using transcriptome analysis console (TAC) software. Additionally, cell proliferation was studied by PrestoBlue assay, and DNA content was evaluated by cell cycle and apoptosis assays. The pro-apoptotic and anti-proliferative mechanisms induced by the overexpression of/exogenously added LOX-PP was evaluated by western blotting and real-time PCR. Results: The expression of the Conclusions: Our results demonstrate the anti-tumorigenic effect of LOX-PP in Y79 RB cells by inducing apoptosis and decreasing proliferation. This effect was mediated by the downregulation of AKT signaling. These results suggest that LOX-PP can be explored as a therapeutic molecule in RB.

Indexed as

Retinal NeoplasmsRetinoblastomaApoptosisCell Line, TumorCell ProliferationEndothelial CellsGene Expression Regulation, NeoplasticHumansPhosphatidylinositol 3-KinasesProtein-Lysine 6-OxidaseProto-Oncogene Proteins c-aktPhosphatidylinositol 3-KinasesProtein-Lysine 6-OxidaseProto-Oncogene Proteins c-akt

Identifiers

PMID38222455

PMCPMC10784223

OpenAlexW4390889369

What OpenQuestion holds

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.