Evidence map›Paper›PMID 38222425›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2023

Leveraging informative missing data to learn about acute respiratory distress syndrome and mortality in long-term hospitalized COVID-19 patients throughout the years of the pandemic.

Emily Getzen, Amelia Lm Tan, Gabriel Brat, Gilbert S Omenn, Zachary Strasser, Consortium for Clinical Characterization of COVID-19 by EHR (4CE) (Collaborative Group/Consortium), Qi Long, John H Holmes, Danielle Mowery

Abstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Emily GetzenPerelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Amelia Lm TanDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA.
Gabriel BratBeth Israel Deaconess Medical Center, Boston, MA.
Gilbert S OmennUniversity of Michigan, Ann Arbor, MI.
Zachary StrasserMassachusetts General Hospital, Boston, MA.
Consortium for Clinical Characterization of COVID-19 by EHR (4CE) (Collaborative Group/Consortium)
Qi LongPerelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
John H HolmesPerelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Danielle MoweryPerelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Biorepository and Coordinating Center for Studies on Cardiovascular Complications of Human Type 1 DiabetesU24DK133700 · NIDDK · UNIVERSITY OF FLORIDA · PI MARK A. ATKINSON · 2022 to 2026
$9.0M
Finding Combinatorial Drug Repositioning Therapy For Alzheimer'S Disease And Related DementiasR01AG066749 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI JIANG, XIAOQIAN, ZHENG, WENJIN JIM · 2020 to 2024
$4.4M
University of Michigan Proteogenomics Data Analysis CenterU24CA210967 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHINNAIYAN, ARUL M, DHANASEKARAN, SARAVANA M · 2016 to 2020
$4.1M
Advancing Analysis of Multi-omics Data in Alzheimer's Disease ResearchRF1AG063481 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LONG, QI · 2019 to 2020
$3.8M
Privacy-preserving methods and tools for handling missing data in distributed health data networksR01GM124111 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI LONG, QI · 2017 to 2020
$2.3M
Robust privacy preserving distributed analysis platform for cancer research: addressing data bias and disparitiesU01CA274576 · NCI · UNIVERSITY OF PENNSYLVANIA · PI JIANG, XIAOQIAN, LONG, QI · 2023 to 2025
$1.2M
NCATS NIH HHS UL1 TR001878NCI NIH HHS U01 CA274576NCI NIH HHS U24 CA210967NIA NIH HHS R01 AG066749NIA NIH HHS RF1 AG063481NIDDK NIH HHS U24 DK133700NIEHS NIH HHS P30 ES017885NIGMS NIH HHS R01 GM124111
6 · The paper itself

Abstract

Electronic health records (EHRs) contain a wealth of information that can be used to further precision health. One particular data element in EHRs that is not only under-utilized but oftentimes unaccounted for is missing data. However, missingness can provide valuable information about comorbidities and best practices for monitoring patients, which could save lives and reduce burden on the healthcare system. We characterize patterns of missing data in laboratory measurements collected at the University of Pennsylvania Hospital System from long-term COVID-19 patients and focus on the changes in these patterns between 2020 and 2021. We investigate how these patterns are associated with comorbidities such as acute respiratory distress syndrome (ARDS), and 90-day mortality in ARDS patients. This work displays how knowledge and experience can change the way clinicians and hospitals manage a novel disease. It can also provide insight into best practices when it comes to patient monitoring to improve outcomes.

Indexed as

COVID-19Respiratory Distress SyndromeHumansPandemicsSARS-CoV-2

Identifiers

PMID38222425
PMCPMC10785926

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.