Evidence map›Paper›PMID 38222354›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2023

Real-world Application of Racial and Ethnic Imputation and Cohort Balancing Techniques to Deliver Equitable Clinical Trial Recruitment.

Kelly J Craig, Yanrong Jerry Ji, Yuxin Chloe Zhang, Alexandra Berk, Amanda Zaleski, Omar Abdelsamad, Henriette Coetzer, Dorothea J Verbrugge, Guangying Hua

Abstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Observational
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kelly J CraigClinical Evidence Development, Aetna Medical Affairs, CVS Health, Wellesley, MA, US.
Yanrong Jerry JiClinical Trial Services, CVS Health, Woonsocket, RI, US.
Yuxin Chloe ZhangClinical Trial Services, CVS Health, Woonsocket, RI, US.
Alexandra BerkClinical Trial Services, CVS Health, Woonsocket, RI, US.
Amanda ZaleskiClinical Evidence Development, Aetna Medical Affairs, CVS Health, Wellesley, MA, US.
Omar AbdelsamadClinical Trial Services, CVS Health, Woonsocket, RI, US.
Henriette CoetzerClinical Trial Services, CVS Health, Woonsocket, RI, US.
Dorothea J VerbruggeClinical Evidence Development, Aetna Medical Affairs, CVS Health, Wellesley, MA, US.
Guangying HuaClinical Trial Services, CVS Health, Woonsocket, RI, US.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enhancing diversity and inclusion in clinical trial recruitment, especially for historically marginalized populations including Black, Indigenous, and People of Color individuals, is essential. This practice ensures that generalizable trial results are achieved to deliver safe, effective, and equitable health and healthcare. However, recruitment is limited by two inextricably linked barriers - the inability to recruit and retain enough trial participants, and the lack of diversity amongst trial populations whereby racial and ethnic groups are underrepresented when compared to national composition. To overcome these barriers, this study describes and evaluates a framework that combines 1) probabilistic and machine learning models to accurately impute missing race and ethnicity fields in real-world data including medical and pharmacy claims for the identification of eligible trial participants, 2) randomized controlled trial experimentation to deliver an optimal patient outreach strategy, and 3) stratified sampling techniques to effectively balance cohorts to continuously improve engagement and recruitment metrics.

Indexed as

EthnicityResearch DesignHumansMinority GroupsPatient Selection

Identifiers

PMID38222354
PMCPMC10785904

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.