Evidence map›Paper›PMID 38222308›Full record

ArticleAmerican heart journal plus : cardiology research and practice2023

Reprograming of transcriptional profile of colonic organoids from patients with high blood pressure by minocycline.

Jing Li, Elaine M Richards, Carl J Pepine, Eileen M Handberg, Steven M Smith, Eyad Alakrad, Chris E Forsmark, Mohan K Raizada

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American heart journal plus : cardiology research and practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 76% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jing LiKey Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, Hubei, China.
Elaine M RichardsDepartment of Physiology and Aging, University of Florida College of Medicine, Gainesville, FL, USA.
Carl J PepineDivisions of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
Eileen M HandbergDivisions of Cardiovascular Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
Steven M SmithDepartment of Pharmaceutical Outcomes & Policy, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Eyad AlakradGastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
Chris E ForsmarkGastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
Mohan K RaizadaDepartment of Physiology and Aging, University of Florida College of Medicine, Gainesville, FL, USA.
University of Florida · USFlorida College · USWuhan Botanical Garden · CN

Funding

Brain-Gut Microbiome-Immune Axis in HypertensionR01HL132448 · NHLBI · UNIVERSITY OF FLORIDA · PI Carl J Pepine, Steven Michael Smith · 2016 to 2026
$4.5M
NHLBI NIH HHS R01 HL132448
6 · The paper itself

Abstract

Minocycline, an anti-inflammatory antibiotic drug, rebalances impaired gut microbiota, attenuates neuroinflammation and lowers high blood pressure in animal models of hypertension and in hypertensive patients. Our objective in this study was to investigate if antihypertensive effects of minocycline involve the expression of gut epithelial genes relevant to blood pressure homeostasis using human colonic 3-dimensional organoid culture and high-throughput RNA sequencing. The data demonstrates that minocycline could restore impaired expression of functional genes linked to viral and bacterial immunity, inflammation, protein trafficking and autophagy in human hypertensive organoids.

Indexed as

Colonic organoidDrug-gene interactionHypertensionMinocyclineTranscriptome

Identifiers

PMID38222308
PMCPMC10785309
OpenAlexW4388002777

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.