Evidence map›Paper›PMID 38221912›Full record

ArticleBioMed research international2024

In Silico Identification of a Potential TNF-Alpha Binder Using a Structural Similarity: A Potential Drug Repurposing Approach to the Management of Alzheimer's Disease.

Edward Jenner Tettevi, Deryl Nii Okantey Kuevi, Balagra Kasim Sumabe, David Larbi Simpong, Mahmoud B Maina, Julius T Dongdem, Mike Y Osei-Atweneboana, Augustine Ocloo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Edward Jenner TetteviDepartment of Biochemistry, Cell and Molecular Biology, School of Biological Science, University of Ghana, Legon, Accra, P.O. Box LG 25, Ghana.ORCID https://orcid.org/0000-0002-2448-2679
Deryl Nii Okantey KueviBiomedical and Public Health Research Unit, Council for Scientific and Industrial Research-Water Research Institute, Accra, P.O. Box M 32, Ghana.ORCID https://orcid.org/0000-0002-0576-3715
Balagra Kasim SumabeBiomedical and Public Health Research Unit, Council for Scientific and Industrial Research-Water Research Institute, Accra, P.O. Box M 32, Ghana.ORCID https://orcid.org/0000-0003-1639-1854
David Larbi SimpongDepartment of Medical Laboratory Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana.ORCID https://orcid.org/0000-0002-9194-3762
Mahmoud B MainaSerpell Laboratory, Sussex Neuroscience, School of Life Sciences, University of Sussex, UK.ORCID https://orcid.org/0000-0002-7421-3813
Julius T DongdemDepartment of Biochemistry and Molecular Medicine, School of Medicine, University for Development Studies, Tamale Campus, Ghana.ORCID https://orcid.org/0000-0001-8477-4721
Mike Y Osei-AtweneboanaBiomedical and Public Health Research Unit, Council for Scientific and Industrial Research-Water Research Institute, Accra, P.O. Box M 32, Ghana.ORCID https://orcid.org/0000-0002-8541-5015
Augustine OclooDepartment of Biochemistry, Cell and Molecular Biology, School of Biological Science, University of Ghana, Legon, Accra, P.O. Box LG 25, Ghana.ORCID https://orcid.org/0000-0003-1249-5349
Council for Scientific and Industrial Research · GHUniversity of Ghana · GHUniversity for Development Studies · GHUniversity of Cape Coast · GHUniversity of Sussex · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder with no conclusive remedy. Methods: Our study repurposed an FDA-approved drug as TNF Results: Metoserpate was selected from 10 compounds similar to Conclusion: Our study has identified metoserpate, a previously FDA-approved antihypertensive agent, as a promising candidate for inhibiting TNF

Indexed as

Alzheimer DiseaseDrug RepositioningHumansMolecular Docking SimulationMolecular Dynamics SimulationTumor Necrosis Factor-alphaYohimbineTumor Necrosis Factor-alphaYohimbine

Identifiers

PMID38221912
PMCPMC10787656
OpenAlexW4390640790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.