Evidence map›Paper›PMID 38221603›Full record

ArticleBiological trace element research2024

The Role of Zinc on Liver Fibrosis by Modulating ZIP14 Expression Throughout Epigenetic Regulatory Mechanisms.

Zeynep Busra Aksoy-Ozer, Ceylan Verda Bitirim, Belma Turan, Kamil Can Akcali

Abstract read
In one paragraph

Article in Biological trace element research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zeynep Busra Aksoy-OzerAnkara University Stem Cell Institute, Ankara, Turkey.ORCID http://orcid.org/0000-0002-8288-0974
Ceylan Verda BitirimAnkara University Stem Cell Institute, Ankara, Turkey.ORCID http://orcid.org/0000-0002-7979-0679
Belma TuranBiophysics Department, Lokman Hekim University Medical School, Ankara, Turkey.ORCID http://orcid.org/0000-0003-2583-9294
Kamil Can AkcaliAnkara University Stem Cell Institute, Ankara, Turkey. canakcali@gmail.com.ORCID http://orcid.org/0000-0002-7816-6938

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc plays a pivotal role in tissue regeneration and maintenance being as a central cofactor in a plethora of enzymatic activities. Hypozincemia is commonly seen with chronic liver disease and is associated with an increased risk of liver fibrosis development and hepatocellular carcinoma. Previously favorable effects of zinc supplementation on liver fibrosis have been shown. However, the underlying mechanism of this effect is not elucidated. Liver fibrosis was induced in mice by using CCl

Indexed as

Cation Transport ProteinsEpigenesis, GeneticLiver CirrhosisZincZinc CompoundsAnimalsCarbon TetrachlorideChloridesDNA-Binding ProteinsHepatocytesHistone DeacetylasesMaleMiceMice, Inbred C57BLPromoter Regions, GeneticTranscription Factor MTF-1Carbon TetrachlorideCation Transport ProteinsChloridesDNA-Binding ProteinsHistone DeacetylasesSLC39A14 protein, mouseTranscription Factor MTF-1Transcription FactorsZinczinc chlorideZinc CompoundsAcetylationEpigeneticsHDACLiver fibrosisZinc

Identifiers

PMID38221603
PMCPMC11442477

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.