Evidence map›Paper›PMID 38221545›Full record

SynthesisNeurosurgical review2024

Efficacy and Safety of Intraoperative Radiotherapy for High-Grade Gliomas: A Systematic Review and Meta-Analysis.

Lucca B Palavani, Leonardo de Barros Oliveira, Pedro Abrahão Reis, Savio Batista, Laís Silva Santana, Lucas Piason de Freitas Martins, Nicollas Nunes Rabelo, Raphael Bertani, Leonardo Christiaan Welling, Eberval Gadelha Figueiredo and 2 more

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurosurgical review, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02685605 (A Multicenter Randomized Phase III Trial on INTraoperative RAdiotherapy in Newly Diagnosed GliOblastoma Multiforme), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02685605 phase3active not recruitingnot on this map

A Multicenter Randomized Phase III Trial on INTraoperative RAdiotherapy in Newly Diagnosed GliOblastoma Multiforme (INTRAGO II)

TypeinterventionalSponsorUniversitätsmedizin MannheimRan2016 to 2026Enrolled314ConditionsGlioblastomaArmsStandard surgery, Intraoperative radiotherapy, Radiochemotherapy, Temozolomide
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Lucca B PalavaniMax Planck University Center, Indaiatuba, São Paulo, Brazil.
Leonardo de Barros OliveiraFaculty of Medicine, State University of Ponta Grossa, Paraná, Brazil.
Pedro Abrahão ReisFaculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Savio BatistaFaculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. saviobatista360@gmail.com.
Laís Silva SantanaFaculdade de Medicina da, Univeridade de São Paulo, São Paulo, Brazil.
Lucas Piason de Freitas MartinsEscola Bahiana de Medicina E Saúde Pública, Salvador, BA, Brazil.
Nicollas Nunes RabeloDivision of Neurosurgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Raphael BertaniDivision of Neurosurgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Leonardo Christiaan WellingFaculty of Medicine, State University of Ponta Grossa, Paraná, Brazil.
Eberval Gadelha FigueiredoDivision of Neurosurgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Wellingson S PaivaDivision of Neurosurgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Iuri Santana NevilleDivision of Neurosurgery, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRUniversidade Estadual de Ponta Grossa · BRUniversidade Federal do Rio de Janeiro · BREscola Bahiana de Medicina e Saúde Pública · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesHigh-grade gliomas (HGGs) are aggressive tumors of the central nervous system that cause significant morbidity and mortality. Despite advances in surgery and radiation therapy (RT), HGG still has a high incidence of recurrence and treatment failure. Intraoperative radiotherapy (IORT) has emerged as a promising therapeutic approach to achieve local tumor control while sparing normal brain tissue from radiation-induced damage.

methodsA systematic review and meta-analysis were conducted following PRISMA guidelines to evaluate the use of IORT for HGG. Eligible studies were included based on specific criteria, and data were independently extracted. Outcomes of interest included complications, IORT failure, survival rates at 12 and 24 months, and mortality.

resultsSixteen studies comprising 436 patients were included. The overall complication rate after IORT was 17%, with significant heterogeneity observed. The IORT failure rate was 77%, while the survival rates at 12 and 24 months were 74% and 24%, respectively. The mortality rate was 62%.

conclusionThis meta-analysis suggests that IORT may be a promising adjuvant treatment for selected patients with HGG. Despite the high rate of complications and treatment failures, the survival outcomes were comparable or even superior to conventional methods. However, the limitations of the study, such as the lack of a control group and small sample sizes, warrant further investigation through prospective randomized controlled trials to better understand the specific patient populations that may benefit most from IORT. However, the limitations of the study, such as the lack of a control group and small sample sizes, warrant further investigation. Notably, the ongoing RP3 trial (NCT02685605) is currently underway, with the aim of providing a more comprehensive understanding of IORT. Moreover, future research should focus on managing complications associated with IORT to improve its safety and efficacy in treating HGG.

Indexed as

Brain NeoplasmsGliomaHumansNeoplasm Recurrence, LocalProspective StudiesRadiotherapyGlioblastomaGliomaHigh-grade gliomaIntraoperative radiotherapyIORTRadiosurgeryRadiotherapy

Identifiers

PMID38221545
OpenAlexW4390876455

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.