Evidence map›Paper›PMID 38219446›Full record

ArticleBrazilian journal of otorhinolaryngology

Deficiency in infiltration of CD8/CD3 positive lymphocytes and macrophages plays a role in lip carcinogenesis: an immunohistochemical study.

Iana Aragão Magalhães, Gabriella Alves Juliao Costa, Marcela Maria Fontes Borges, Anna Clara Aragão Matos Carlos, Karine Cestaro Mesquita, Larissa Mont Alverne de Arruda, Maria do Perpétuo Socorro Saldanha Cunha, Fabrício Bitu Sousa, Paulo Goberlânio de Barros Silva

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. The p16 Immunostaining Predicts the Risk of Recurrence in Prostate Cancer.Asian Pacific journal of cancer prevention : APJCP · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Iana Aragão MagalhãesUnichristus, Departamento de Odontologia, Fortaleza, CE, Brazil.
Gabriella Alves Juliao CostaUnichristus, Departamento de Odontologia, Fortaleza, CE, Brazil.
Marcela Maria Fontes BorgesUniversidade Federal do Ceará, Faculdade de Farmácia, Odontologia e Enfermagem, Departamento de Clínica Dentária, Divisão de Patologia Oral, Fortaleza, CE, Brazil.
Anna Clara Aragão Matos CarlosUniversidade Federal do Ceará, Faculdade de Farmácia, Odontologia e Enfermagem, Departamento de Clínica Dentária, Divisão de Patologia Oral, Fortaleza, CE, Brazil.
Karine Cestaro MesquitaUnichristus, Departamento de Odontologia, Fortaleza, CE, Brazil.
Larissa Mont Alverne de ArrudaHospital Haroldo Juaçaba, Instituto Cearense do Câncer, Fortaleza, CE, Brazil.
Maria do Perpétuo Socorro Saldanha CunhaHospital Haroldo Juaçaba, Instituto Cearense do Câncer, Fortaleza, CE, Brazil.
Fabrício Bitu SousaUnichristus, Departamento de Odontologia, Fortaleza, CE, Brazil; Universidade Federal do Ceará, Faculdade de Farmácia, Odontologia e Enfermagem, Departamento de Clínica Dentária, Divisão de Patologia Oral, Fortaleza, CE, Brazil.
Paulo Goberlânio de Barros SilvaUnichristus, Departamento de Odontologia, Fortaleza, CE, Brazil; Universidade Federal do Ceará, Faculdade de Farmácia, Odontologia e Enfermagem, Departamento de Clínica Dentária, Divisão de Patologia Oral, Fortaleza, CE, Brazil; Hospital Haroldo Juaçaba, Instituto Cearense do Câncer, Fortaleza, CE, Brazil. Electronic address: paulo_goberlanio@yahoo.com.br.
Universidade Federal do Ceará · BRUnichristus · BRHospital Haroldo Juaçaba · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the immunoexpression profile for CD8, CD3, CD20 and CD68 in the process and carcinogenesis of Carcinoma of the vermilion lip.

methodsAverage cell count with positive expression for CD3, CD8, CD20 and CD68. The CD8/CD3 ratio calculated in the region was based on the percentage of positive cells in a total of malignant cells. Kruska-Wallis/Dunn, Mann-Whitney and Spearman correlation tests (SPSS, p < 0.05) were used.

resultsIn the Aquitic Cheilitis samples, there was an increase in intraepithelial CD8+ and CD68+. In LSCCs, there was an increase in peritumoral and intratumoral CD3+, CD8+, CD20+ and CD68+ cells. In peritumoral LSCC, CD3+ and CD8+ showed a direct correlation (p = 0.004), and CD68+ and CD8+ (p = 0.017). In the intraepithelial region, CD8+ correlated with CD20+ (p = 0.014) and CD68+ (p = 0.013). In the CAs, CD3 (p < 0.001) and CD8 (p = 0.025) correlated intraepithelial and subepithelial. In LSCC CD3+ (p = 0.002), CD8+ (p = 0.001) and CD68+ (p = 0.030) had intra and peritumoral correlation.

conclusionCD68+ is the first interacting cell with the greatest capacity to migrate to the tumor and interact with CD3, CD8 and CD20. Apparently, CD20 affects perineural invasion. LEVEL OF EVIDENCE: Level 2.

Indexed as

CarcinomaLipCarcinogenesisCD8-Positive T-LymphocytesHumansMacrophagesPrognosisLip neoplasmsLymphocytesTumor-infiltratingTumor microenvironment

Identifiers

PMID38219446
PMCPMC10826144
OpenAlexW4389955886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.