Evidence map›Paper›PMID 38219015›Full record

ArticleBiophysical journal2024

An intracellular hydrophobic nexus critical for hERG1 channel slow deactivation.

Whitney A Stevens-Sostre, Lisandra Flores-Aldama, Daniel Bustos, Jin Li, João H Morais-Cabral, Lucie Delemotte, Gail A Robertson

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Molecular Determinants of Voltage-Dependent Gating in Kv11.1 Channels.Advances in experimental medicine and biology · 2026
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Whitney A Stevens-SostreDepartment of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Lisandra Flores-AldamaDepartment of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Daniel BustosCentro de Investigación de Estudios Avanzados Del Maule (CIEAM), Vicerrectoría de Investigación y Postgrado, Universidad Católica Del Maule, Talca, Chile; Laboratorio de Bioinformática y Química Computacional (LBQC), Departamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica Del Maule, Talca, Chile.
Jin LiDepartment of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
João H Morais-CabralInstituto de Investigação e Inovação Em Saude da Universidade Do Porto (i3S); Instituto de Biologia Molecular e Celular, Universidade Do Porto, Porto, Portugal.
Lucie DelemotteKTH Royal Institute of Technology, Science for Life Laboratory, Stockholm, Sweden.
Gail A RobertsonDepartment of Neuroscience, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. Electronic address: garobert@wisc.edu.
University of Wisconsin–Madison · USCatholic University of the Maule · CLScience for Life Laboratory · SEUniversidade do Porto · PT

Funding

Training Program in Translational Cardiovascular Science (TPTCS)T32HL007936 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Gail A Robertson · 2001 to 2026
$11.6M
Translational Control of Cardiac ExcitabilityR01HL131403 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Gail A Robertson · 2016 to 2026
$6.0M
Allosteric Regulation of KCNH ChannelsR01NS081320 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERTSON, GAIL A · 2012 to 2022
$3.4M
Biogenesis of hERG1a/1b ion channels in health and disease model cardiomyocytesK99HL169909 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI FLORES ALDAMA, LISANDRA · 2023 to 2024
$339k
Investigation of the Role of the KCNH Voltage-Gated Potassium Channel Intracellular Domains in GatingK00EY036250 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI STEVENS-SOSTRE, WHITNEY ALEXANDRA · 2024 to 2024
$77k
Investigation of the Role of the KCNH Voltage-Gated Potassium Channel Intracellular Domains in GatingF99NS125824 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI STEVENS-SOSTRE, WHITNEY ALEXANDRA · 2021 to 2023
$53k
NEI NIH HHS K00 EY036250NHLBI NIH HHS K99 HL169909NHLBI NIH HHS R01 HL131403NHLBI NIH HHS T32 HL007936NINDS NIH HHS F99 NS125824NINDS NIH HHS R01 NS081320
6 · The paper itself

Abstract

Slow deactivation is a critical property of voltage-gated K

Indexed as

Hydrophobic and Hydrophilic InteractionsAmino Acid SequenceAnimalsERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsHEK293 CellsHumansIntracellular SpaceIon Channel GatingProtein DomainsERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsKCNH2 protein, human

Identifiers

PMID38219015
PMCPMC11309987
OpenAlexW4390862229

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.