ArticleScientific reports2024
Socioeconomic inequalities in early adulthood disrupt the immune transcriptomic landscape via upstream regulators.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Adaptive immune responses to vaccination reflect social status at first exposure in female rhesus macaques.bioRxiv : the preprint server for biology · 2026Article
- Pelvic Inflammatory Disease: A Narrative Review of Disparities Between Black and White Women in the United States and Strategies for Improvement.Journal of patient-centered research and reviews · 2026Review
- Peer victimization in adolescence alters gene expression and cytokine profiles during transition to adulthood.Brain, behavior, & immunity - health · 2025Article
- Lifespan Fluidity and Its Biological Limitations in Socio-Economic Health Differences.Journal of the American Geriatrics Society · 2025Article
- Life Expectancy and Health Expectancy in the Twenty-first Century: The Unthinkable, the Inconceivable, and the Unknowable.Demography · 2025Article
- Epigenetic biomarkers of socioeconomic status are associated with age-related chronic diseases and mortality in older adults.PNAS nexus · 2025Article
- Life course socioeconomic position, intergenerational social mobility, and mortality among Brazilian public servants in the ELSA-Brasil cohort.Cadernos de saude publica · 2025Article
- Increased Herpes simplex virus 1, Toxoplasma gondii and Cytomegalovirus antibody concentrations in severe mental illness.Translational psychiatry · 2024Article
- Socioeconomic status across the early life course predicts gene expression signatures of disease and senescence.Journal of epidemiology and community health · 2024Article
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Abstract
Disparities in socio-economic status (SES) predict many immune system-related diseases, and previous research documents relationships between SES and the immune cell transcriptome. Drawing on a bioinformatically-informed network approach, we situate these findings in a broader molecular framework by examining the upstream regulators of SES-associated transcriptional alterations. Data come from the National Longitudinal Study of Adolescent to Adult Health (Add Health), a nationally representative sample of 4543 adults in the United States. Results reveal a network-of differentially expressed genes, transcription factors, and protein neighbors of transcription factors-that shows widespread SES-related dysregulation of the immune system. Mediational models suggest that body mass index (BMI) plays a key role in accounting for many of these associations. Overall, the results reveal the central role of upstream regulators in socioeconomic differences in the molecular basis of immunity, which propagate to increase risk of chronic health conditions in later-life.
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